| Project/Area Number |
20700318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kurume University |
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Principal Investigator |
SOTOGAKU Naoki Kurume University, 医学部, 講師 (60368884)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経再生 / 神経可塑性 / コンドロイチン硫酸 / 神経幹細胞 / 細胞接着 / 細胞遊走 / 細胞内情報伝達 |
|---|
| Research Abstract |
Chondroitin sulfate (CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion of neural stem cells. Several genes including H2-Q6 (histocompatibilty 2, class I antigen) and CCL12 (chemokine (C-C motif) ligand 12) were enhanced mRNA levels in CS-E polysaccharide-treated neural stem cells.
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