Imbalanced expression of tau and tubulin is an essential step for pathogenesis of tauopathy.

• Project/Area Number: 20700324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Doshisha University
• Principal Investigator: MIYASAKA Tomohiro Doshisha University, 生命医科学部, 助教 (90342857)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: タウ / 認知症 / 線虫 / 神経変性 / 微小管 / チューブリン / アルツハイマー病 / RNAi / 神経細胞死

Research Abstract

Tauopathy is a major category of age-dependent neurodegenerative disease, which defined by numerous neuron-loss associated with filamentous phospho-tau inclusions and microtubule loss in affected neurons. In this study, we found that the both of over expression of tau and/or down regulation of tubulin can induce tauopathy-like neuronal dysfunction in C.elegans. Thus, we concluded that the imbalanced expression of tau and tubulin is an essential step for pathogenesis of tauopathy.

Research Products

• [Journal Article] Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo: Tau hyperphosphorylation and microtubules stability in vivo. (2008)
  • Author(s): Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE.
  • Journal Title: J Neurosci vol.28 Pages: 12798-12807
  • Peer Reviewed
• [Journal Article] Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo : Tau hvnernhosnhorvlation and microtubules stability in vivo (2008)
  • Author(s): Planel E, et.al.
  • Journal Title: Journal of Neuroscience 28 Pages: 12798-12807
  • Peer Reviewed
• [Presentation] Imbalanced expression of tau and tubulin may be a key step to tauopathy. (2008)
  • Author(s): Miyasaka T, Ihara Y.
  • Organizer: The 15th Takeda Science Foundation Symposium on Bioscience "Cell Death: what have we learned and what will we learn?"
  • Place of Presentation: 東京
  • Year and Date: 2008-12-03
• [Presentation] Imbalanced expression of tau and tubulin may be a key step to tauopathy (2008)
  • Author(s): Miyasaka T and Ihara Y
  • Organizer: The 15th Takeda Science Foundation Symrosium on Bioscience "Cell Death : what have we learned and what will we learn?"
  • Place of Presentation: 東京
  • Year and Date: 2008-12-03