| Project/Area Number |
20700332
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tamagawa University |
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Principal Investigator |
ARIMURA Nariko Tamagawa University, 脳科学研究所, グローバルCOE准教授 (20420375)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経伝達物質 / 受容体 / CRMP-2 / キネシン / ダイニン / 順行性輸送 / 逆行性輸送 / 軸索 / 神経 / 輸送 / TrkB |
|---|
| Research Abstract |
The brain consists of the remarkably fine neural circuits. This circuits are made of axons, and CRMP-2 previously had been identified as a key molecule in axon formation. I analyzed the functional meaning of CRMP-2 in axon formation, and obtained the following results : 1) CRMP-2 regulates anterograde TrkB transport in axon through the association with Slp1 and Rab27. 2) CRMP-2 binds directly to cytoplasmic dynein, a motor protein of retrograde transport, and negatively regulates its function. These results suggest that CRMP-2 play a role in axon formation through regulating the molecular transport in axon.
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