| Project/Area Number |
20700333
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
TAYA Shinichiro Nagoya University, 神経研究所・診断研究部, 室長 (60362232)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 精神 / 神経疾患の病態と治療 / 統合失調症 / 脳神経疾患 / 脳・神経 / 神経科学 |
|---|
| Research Abstract |
Schizophrenia is a disease affecting about 1% of the population in the world. However, mpathogenesis of schizophrenia is unclear, several hypotheses are reported. To understand molecular level of schizophrenic pathogenesis, I focused on DISC1 and its interacting molecules. In this study, I showed that DISC1 and its interacting molecules regulate axon elongation, synapse formation, and neuronal migration. These results suggest that the functional analysis of DISC1 leads to molecular level of schizophrenic pathogenesis.
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