| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
New neurons are continuously generated in the mammalian subventricular zone, which migrate for a long distance through the meshwork of astrocytic processes toward the olfactory bulb. The molecular mechanism that regulates the interaction between the migrating neurons and surrounding astrocytes had been unknown. In this study, we demonstrated that the new neurons use a diffusible protein, Slitl, to dynamically control the morphology and arrangement of the astrocytes in the migratory route, which is required for their rapid and long-range migration in the adult brain. We also found that this neuron-astrocyte interaction is also involved in the migration of new neurons into the damaged area during neuronal regeneration processes after brain infarction.
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