The role of Slit in migration of new neurons in the adult brain under physiological and pathological conditions.
Project/Area Number |
20700337
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya City University |
Principal Investigator |
KANEKO Naoko Nagoya City University, 大学院・医学研究科, 助教 (20464571)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 発生 / 分化 / 老化 / 脳室下帯 / ニューロン新生 / 細胞移動 / ニューロン再生 / Slit / Robo / 再生医学 / 神経科学 / 脳・神経 / 脳神経疾患 / 発生・分化 |
Research Abstract |
New neurons are continuously generated in the mammalian subventricular zone, which migrate for a long distance through the meshwork of astrocytic processes toward the olfactory bulb. The molecular mechanism that regulates the interaction between the migrating neurons and surrounding astrocytes had been unknown. In this study, we demonstrated that the new neurons use a diffusible protein, Slitl, to dynamically control the morphology and arrangement of the astrocytes in the migratory route, which is required for their rapid and long-range migration in the adult brain. We also found that this neuron-astrocyte interaction is also involved in the migration of new neurons into the damaged area during neuronal regeneration processes after brain infarction.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.2010
Author(s)
Kaneko N, Marin O, Koike M, Hirota Y, Uchiyama Y, Wu J, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein J, Sawamoto K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.2010
Author(s)
Kaneko N, Marin O, Koike M, Hirota Y, Uchiyama Y, Wu J, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein J, Sawamoto K
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Journal Title
Neuron
Volume: 67
Pages: 212-223
Related Report
Peer Reviewed
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[Journal Article] Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus.2009
Author(s)
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] 成体脳内を移動する新生ニューロンのSlit1分泌を介した移動経路維持メカニズム2010
Author(s)
金子奈穂子, Oscar Marin, 小池正人, 廣田ゆき, 内山安男, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, 岡野栄之, John L.R.Rubenstein, 澤本和延
Organizer
第33回日本分子生物学会年会
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
2010-12-08
Related Report
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[Presentation] New neurons form and maintain their path of astrocytic processes for rapid migration in the adult brain.2010
Author(s)
Naoko Kaneko, Oscar Marin, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R.Rubenstein, Kazunobu Sawamoto
Organizer
第53回日本神経化学会大会
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
2010-09-03
Related Report
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[Presentation] グリアとの相互作用による新生ニューロンの 移動制御と傷害脳の再生過程の解析2010
Author(s)
金子奈穂子, Oscar Marin, 小池正人, 廣田ゆき, 内山安男, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, 岡野栄之, John L.R.Rubenstein, 澤本和延
Organizer
平成22年度名古屋市立大学医学例会
Place of Presentation
名古屋市立大学(愛知県)
Year and Date
2010-06-15
Related Report
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[Presentation] Rubenstein, Kazunobu Sawamoto Dynamic interaction of migrating neurons with glial cells in adult brain.2010
Author(s)
Naoko Kaneko, Oscar Marin, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R.
Organizer
第9回日本再生医療学会総会(第2回日本再生医療学会Young Investigator's Award 受賞者講演)
Place of Presentation
国際会議場,広島県
Year and Date
2010-03-18
Related Report
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[Presentation] Dynamic interaction of migrating neurons with glial cells in adult brain. (グリア細胞との相互作用による新生ニューロンの移動制御機構) (第2回 Young Investigator's Award受賞講演)2010
Author(s)
金子奈穂子, Oscar Marin, 小池正人, 廣田ゆき, 内山安男, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, 岡野栄之, John L.R.Rubenstein, 澤本和延
Organizer
第9回日本再生医療学会総会
Place of Presentation
広島国際会議場
Year and Date
2010-03-18
Related Report
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[Presentation] In vivo imaging of sensory input-dependent neurogenesis in the adult olfactory bulb2009
Author(s)
Sawada, M., Kaneko, N., Wake, H., Inada, H., Kato Y., Yanagawa, Y., Nenoto, T., Nabekura, J., Sawamoto, K.
Organizer
第32回日本神経科学大会
Place of Presentation
名古屋国際会議場
Year and Date
2009-09-17
Related Report
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[Presentation] Enhanced oligodendrogenesis and neurogenesis in the subventriclar zone of neonatal mouse brain following Hypoxia/ischemia.2009
Author(s)
Kako, E., Kaneko, N., Hida, H., Sobue, K., Togari, T., Sawamoto, K.
Organizer
第32回日本神経科学大会
Place of Presentation
名古屋国際会議場
Year and Date
2009-09-16
Related Report
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[Presentation] Slit-Roboシグナルによる新生ニューロンの移動制御機構2009
Author(s)
金子奈穂子, Oscar Marin, 小池正人, 村上富, 内山安男, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, 岡野栄之, John L.R.Rubenstein, 澤本和延
Organizer
第7回曽生物学セミナー
Place of Presentation
岡崎
Year and Date
2009-08-28
Related Report
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[Presentation] Slit-Robo signaling regulates migration of neurons under physiological and pathological conditions.2009
Author(s)
Naoko Kaneko, Oscar Marin, Koike, Yuki Hirota, Fujio Murakami, Jane Wu, Yasuop Uchiama, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R Rubenstein, Kazunobu Sawamoto
Organizer
国際生理学会
Place of Presentation
京都国際会館
Year and Date
2009-07-31
Related Report
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