| Project/Area Number |
20700339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
INATOME Ryoko Tokyo University of Pharmacy and Life Science, 生命科学部, 研究員 (90408691)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞内情報伝達 / 活性酸素 / レドックス / ミトコンドリア |
|---|
| Research Abstract |
During neural circuit formation repulsive and attractive factors such as semaphorins and netrin play a crucial role in axon guidance. However, their intracellular mechanisms are largely unknown. We have previously identified several novel proteins named CRAM, CRAG, M-septin, MITOL, which were involved in semaphoring-mediated signaling. Although exact roles of these molecules in neural development remained unclarified, these proteins were suggested to be involved in redox signaling via reactive oxygen species (ROS). Indeed, we observed the nuclear translocation and activation of CRAG in response to ROS generated by semaphorin stimulation. This fact suggested a novel concept that axon guidance signaling is redox reaction. Further studies may make clear the molecular mechanism of redox signaling in neural development. In addition, these studies may shed light on the mechanisms and develop new therapy for neuronal degenerative disorders.
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