| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
In the brain of the GM3 only mice that defected normal gangliosides composition, localization of lipid raft proteins shifted to non-raft region with aging. Ninjurin2, reported as one of the neuroregeneration-related molecules, was down-regulated in the GM3 only mice in central nervous system. Ninjurin2 localized at raft region and related to homophilic cell adhesion and increased neurite outgrowth. These date suggested that disturbance of raft compositions accelerate neurodegeneration in the GM3 only mice.
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