| Project/Area Number |
20700348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | University of Fukui |
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Principal Investigator |
IKEDA Hiroshi University of Fukui, 大学院・工学研究科, 准教授 (80377473)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 痛覚 / グリア細胞 / イメージング / シナプス可塑性 / 脊髄後角 / 免疫染色 / 痛覚過敏 / 電位イメージング / 中枢性感作 / ラット |
|---|
| Research Abstract |
In this study, we examined the change of morphology of glial cells, the contribution of glial cells to the neuronal excitation and the change of glial activity especially P2X4 receptors in the rat spinal dorsal horn under hyperalgesia. In the neuropathic pain, the number of activated form of microglia and the Ca2+ signals via P2X4 receptor are increased, and the neuronal excitation evoked by single-pulse stimulation was decreased glial inhibitor or P2X receptor antagonist.
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