| Project/Area Number |
20700350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Osaka University |
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Principal Investigator |
TACHIBANAKI Shuji Osaka University, 大学院・生命機能研究科, 准教授 (70324746)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 視細胞 / 錐体 / GRK / Sモジュリン / 順応 / RGS9 / cGMP / Sモミュリン・s26 / 発色団代謝経路 / ALOL反応 |
|---|
| Research Abstract |
In vertebrate retina, there are two types of photoreceptor cells, called rods and cones. The time resolution of cone mediated vision is higher than that of rod-mediated vision. This higher time-resolution depends on shorter responses of cones. It is also known that the range of light-intensity that cone can mediate is wider than that of rod. In this study, the underlying mechanisms of cone-specific responses are studied. The results show that the lifetime of activated enzymes, working in the phototransduction mechanism, are shorter in cones than in rods. And It is also revealed that the enzymatic activities in the phototransduction mechanism are more highly modulated in cones than in rods. These findings show molecular bases of the cone specific photoresponses.
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