Memory formation based on reward in inferior temporal cortex

• Project/Area Number: 20700356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: SUGASE Yasuko National Institute of Advanced Industrial Science and Technology, ヒューマンライフテクノロジー研究部門, 主任研究員 (40357257)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 認知 / 言語 / 記憶 / 情動 / 学習 / 連合学習 / 下側頭皮質

Research Abstract

To investigate neuronal processing in perirhinal cortex during stimulus-stimulus-reward associations, we recorded single unit data from neurons in the perirhinal cortex using two monkeys performing bar-release response trials imbedded within a delayed conditioning paradigm. The neurons in the perirhinal cortex have signals about stimulus identity, predicted reward contingency, and memory for a preceding stimulus. The pattern cue elicited responses during the conditional association task were not simply related to physical stimulus characteristics. These results showed that most of the neurons had activity distinguishing the conditional association task, suggesting an important role of perirhinal cortex when stimulus-stimulus sequences lead to different reward outcomes.

Research Products

• [Journal Article] Short-Term Memory Trace in Rapidly Adapting Synapses of Inferior Temporal Cortex. (2008)
  • Author(s): Sugase-Miyamoto Y. et al.
  • Journal Title: PLoS computational biology 4
  • Peer Reviewed
• [Presentation] Encoding of stimulus-stimulus association and reward contingency in monkey perirhinal cortex during conditional association task (2009)
  • Author(s): 内山薫、松本有央、設樂宗孝、菅生康子
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] Encoding of visual stimulus, memroy and reward expectation in monkey perirhinal cortex during delayed conditioning (2009)
  • Author(s): 内山薫、松本有央、設樂宗孝、菅生康子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋,愛知
  • Year and Date: 2009-09-18
• [Presentation] Encoding of visual stimulus, memory and reward expectation in monkey perirhinal cortex during delayed conditioning (2009)
  • Author(s): 内山薫、松本有央、設楽宗孝、菅生康子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋、愛知
  • Year and Date: 2009-09-18
• [Presentation] Visual, memory and reward expectation signals in monkey perirhinal cortex during delayed conditioning (2008)
  • Author(s): 内山薫、松本有央、設樂宗孝、Richmond BJ(NIMH, NIH)、菅生康子
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] Experience-dependent stimulus-reward/non-reward association during delayed conditioning (2008)
  • Author(s): 内山薫、松本有央、設樂宗孝、菅生康子
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10