Maintenance and self-renewal mechanism of muscle satellite cells
Project/Area Number |
20700358
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Osaka University |
Principal Investigator |
FUKADA So-ichiro Osaka University, 薬学研究科, 助教 (20432445)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 骨格筋生理・病態学 / 筋衛星細胞 / 維持機構 / カルシトニン受容体 / 幹細胞 / 骨格筋 / ニッチ / 再生 / ニッチェ |
Research Abstract |
I investigated the roles of quiescent satellite cell-specific genes in vitro and in vivo. One of specific genes, calcitonin receptor suppressed proliferation and migration of satellite cells in vitro. In addition, hesr1 and 3 double knock mice exhibited the decreased number of muscle satellite cells in vivo. Furthermore self-renewal potential of muscle satellite cells were different among mouse strain, and the potential were directly related to muscle weight.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Genetic background affects properties of satellite cells and mdx phenotypes (*corresponding author).2010
Author(s)
Fukada S*, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H
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Journal Title
American Journal of Pathology (in press)
Related Report
Peer Reviewed
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[Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells2010
Author(s)
Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada S, Yamamoto H, Yamanaka S, Nakahata T, Heike T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009
Author(s)
Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada S, Yamamoto H, Motohashi N, Suzuki YM, Takeda S, Heike T, Nakahata T
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Journal Title
FASEB J. 23(6)
Pages: 1907-19
Related Report
Peer Reviewed
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[Journal Article] Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis. (*corresponding author)2008
Author(s)
Segawa M, Fukada S*, Yamamoto Y, Yahagi H, Kanematsu M, Sato M, Ito T, Uezumi A, Hayashi S, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H
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Journal Title
Exp. Cell Res. 314
Pages: 3232-3244
Related Report
Peer Reviewed
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