Analyses of infertility of HP1γ mutant mice
| Project/Area Number |
20700363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Kanazawa University |
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Principal Investigator |
NARUSE Chie Kanazawa University, 学際科学実験センター, 助教 (30372486)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | HP1 / マウス / 生殖細胞 / ヒストン修飾 / エピジェネティクス / 減数分裂 |
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| Research Abstract |
We obtained HP1 gamma mutant mice and found that all homozygous mice were infertile as a result of defects in meiosis. Some kinds of histone methylation at pericentromeric heterochromatin were reduced in the mutant spermatocytes and spermatogonia. Moreover, a methyltransferase of H3K9 in spermatocytes could not accumulate in the mutant spermatocytes. These findings suggest that HP1 gamma is essential for recruitment of histone modification factors at pericentromeric heterochromatin and histone modifications are required for progression of meiosis.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] A novel beta-myosin heavy chain gene mutation, p. Met531Arg, identified in isolated left ventricular noncompaction in humans, resulted in left ventricular hypertrophy that progressed to dilation in a mouse model.2008
Author(s)
Kaneda, T. *, Naruse, C. *, (*は共同筆頭著者) Kawashima, A., Fujino, N., Oshima, T., Namura, M., Nunoda, S., Mori, S., Konno, T., Ino, H., Yamagishi, M., Masahide Asano
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Journal Title
Clinical Science (London) 114
Pages: 431-440
Related Report
Peer Reviewed
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[Presentation] 減数分裂におけるHP1γの機能解析2008
Author(s)
成瀬智恵, 高田幸, Yael Costa, 阿部可奈恵, 柿内太, James Turner, 古関明彦, 浅野雅秀
Organizer
第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
Place of Presentation
神戸ポートアイランド(兵庫県)(ポスター発表)
Year and Date
2008-12-09
Related Report
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[Presentation] 減数分裂およびPGCにおけるHP1γの機能2008
Author(s)
成瀬智恵, 高田幸, Yael Costa, 阿部可奈恵, 柿内太, James Turner, 古関明彦, 浅野雅秀
Organizer
第2回日本エピジェネティクス研究会年会
Place of Presentation
東レ総合研修センター(静岡県)(ポスター発表)
Year and Date
2008-05-09
Related Report
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