Analysis of miRNA functions from miRNA knockout mouse

Research Project

Project/Area Number	20700364
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Laboratory animal science
Research Institution	Osaka University
Principal Investigator	HASUWA Hidetoshi Osaka University, 微生物病研究所, 助教 (50343249)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	マイクロRNA / 遺伝子改変動物 / ノックアウトマウス / 翻訳制御 / miRNA
Research Abstract	MicroRNAs (miRNAs) are endogenous small non-coding RNAs In mammals, the role of miRNAs is indicated in a few miRNAs, but the understanding of a relationship between the impairment of miRNA and diseases in animals is not clearly demonstrated. I tried to establish the miRNA knockout mouse and revealed that reproductive function was regulated by miRNA. Furthermore, I have clarified a real target gene related with phenotype using the miRNA knockout mouse.

Report

(3 results)