Development of computational biomechanics of gastric mixing

• Project/Area Number: 20700373
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: IMAI Yohsuke Tohoku University, 大学院・工学研究科, 助教 (60431524)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 消化器 / 食塊攪拌 / バイオメカニクス / 生理流体力学 / 計算力学 / 生物・生体工学 / 計算物理 / モデル化 / 流体 / 生理学

Research Abstract

We developed a computational fluid dynamics model of gastric mixing. Moving wall condition of antral contraction wave and free-surface condition of gastric gas were given as boundary conditions of the numerical model. We investigated the effects of physiological conditions such as the viscosity and volume of food bolus and the antral contraction wave pattern on the mixing efficiency and fluid stress in the stomach.

Research Products

• [Journal Article] Patient-specific modelling of pulmonary airflow using GPU cluster for the application in medical practice (2011)
  • Author(s): Miki, T., Wang, X., Aoki, T., Imai, Y., Ishikawa, T., Takase, K., Yamaguchi, T.
  • Journal Title: Computer Methods in Biomechanics and Biomedical Engineering in press
  • Peer Reviewed
• [Journal Article] A fourth-order Cartesian local mesh refinement method for the computational fluid dynamics of physiological flow in multi-generation branched vessels (2011)
  • Author(s): Miki, T., Imai, Y., Ishikawa, T., Wada, S., Aoki, T., Yamaguchi, T.
  • Journal Title: International Journal for Numerical Methods in Biomedical Engineering Vo.27 Pages: 424-435
  • Peer Reviewed
• [Journal Article] Margination of red blood cells infected by Plasmodium falciparum in a microvessel (2011)
  • Author(s): Imai, Y., Nakaaki, K., Kondo, H., Ishikawa, T., Lim, C.T., Yamaguchi, T.
  • Journal Title: Journal of Biomechanics Vol.44 Pages: 1553-1558
  • Peer Reviewed
• [Journal Article] A fourth-order Cartesian local mesh refinement method for the computational fluid dynamics of physiological flow in multi-generation branched vessels (2011)
  • Author(s): T.Miki
  • Journal Title: International Journal for Numerical Methods in Biomedical Engineering Volume: (未定 印刷中)
  • Peer Reviewed
• [Journal Article] Margination of red blood cells infected by Plasmodium falciparum in a microvessel (2011)
  • Author(s): Y.Imai
  • Journal Title: Journal of Biomechanics Volume: (未定 印刷中)
  • Peer Reviewed
• [Journal Article] Modeling of hemodynamics arising from malaria infection (2010)
  • Author(s): Imai, Y., Kondo, H., Ishikawa, T., Lim, C.T., Yamaguchi, T.
  • Journal Title: Journal of Biomechanics Vol.43 Pages: 1386-1393
  • Peer Reviewed
• [Journal Article] Particle-based methods for multiscale modeling of blood flow in the circulation and in devices : challenges and future directions (2010)
  • Author(s): Yamaguchi, T., Ishikawa, T., Imai, Y., Matsuki, N., Xenos, M., Dengand, Y., Bluestein, D.
  • Journal Title: Annals of Biomedical Engineering Vol.38 Pages: 1225-1235
  • Peer Reviewed
• [Journal Article] ATP transport in saccular cerebral aneurysms at arterial bends (2010)
  • Author(s): Imai, Y., Sato, K., Ishikawa, T., Comerford, A., David, T., Yamaguchi, T.
  • Journal Title: Annals of Biomedical Engineering Vol.38 Pages: 927-934
  • Peer Reviewed
• [Journal Article] Modeling of hemodynamics arising from malaria infection (2010)
  • Author(s): Y.Imai
  • Journal Title: Journal of Biomechanics Volume: 43 Pages: 1386-1393
  • Peer Reviewed
• [Journal Article] ATP transport in saccular cerebral aneurysms at arterial bends (2010)
  • Author(s): Y.Imai
  • Journal Title: Annals of Biomedical Engineering 38 Pages: 927-924
  • Peer Reviewed
• [Journal Article] Particle-based methods for multiscale modeling of blood flow in the circulation and in devices : challenges and future directions (2010)
  • Author(s): T.Yamaguchi
  • Journal Title: Annals of Biomedical Engineering 38 Pages: 1225-1235
  • Peer Reviewed
• [Journal Article] Hemodynamic analysis of microcirculation in malaria infection (2009)
  • Author(s): Kondo, H., Imai, Y., Ishikawa, T., Lim, C.T., Yamaguchi, T.
  • Journal Title: Annals of Biomedical Engineering Vol.37 Pages: 702-709
  • Peer Reviewed
• [Journal Article] Hemodynamic analysis of microcirculation in malaria infection (2009)
  • Author(s): H.Kondo
  • Journal Title: Annals of Biomedical Engineering 37 Pages: 702-709
  • Peer Reviewed
• [Journal Article] Inflow into saccular cerebral aneurysms at arterial bends (2008)
  • Author(s): Y. Imai
  • Journal Title: Annals of Biomedical Engineering 36 Pages: 1489-1495
  • Peer Reviewed
• [Journal Article] Three-dimensional simulation of blood flow in malaria infection (2008)
  • Author(s): Y. Imai
  • Journal Title: Proceedings of 13th International Conference on Biomedical Engineering Pages: 133-133
  • Peer Reviewed
• [Journal Article] A numerical model of blood flow with malaria infected red blood cells (2008)
  • Author(s): Y. Imai
  • Journal Title: Journal of Biomechanics 41
  • Peer Reviewed
• [Presentation] 胃内容物攪拌の数値流体力学モデルの開発 (2011)
  • Author(s): 今井陽介, 小林生馬, 石田駿一, 石川拓司, 山口隆美
  • Organizer: 日本機械学会第23回バイオエンジニアリング講演会
  • Place of Presentation: 熊本市
  • Year and Date: 2011-01-09
• [Presentation] 胃内容物流れの数値シミュレーション:内容物量の影響 (2010)
  • Author(s): 小林生馬, 今井陽介, 石田駿一, 石川拓司, 山口隆美
  • Organizer: 日本機械学会第21回バイオフロンティア講演会
  • Place of Presentation: 金沢市
  • Year and Date: 2010-11-12
• [Presentation] A numerical study on fluid motion in the stomach (2010)
  • Author(s): Kobayashi, I., Imai, Y., Ishida, S., Ishikawa, Yamaguchi, T.
  • Organizer: 6th World Congress on Biomechanics
  • Place of Presentation: Singapore.シンガポール
  • Year and Date: 2010-08-06
• [Presentation] A numerical study on fluid motion in the stomach (2010)
  • Author(s): I.Kobayashi
  • Organizer: 6th World Congress on Biomechanics
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2010-08-06
• [Presentation] 粒子法を用いた胃内容物攪拌の数値シミュレーション (2010)
  • Author(s): 小林生馬, 今井陽介, 石田駿一, 石川拓司, 山口隆美
  • Organizer: 日本機械学会東北支部第45期講演会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-03-12
• [Presentation] 粒子法を用いた胃内容物撹拌の数値シミュレーション (2010)
  • Author(s): 小林生馬
  • Organizer: 日本機械学会東北支部 第45期講演会
  • Place of Presentation: 仙台
  • Year and Date: 2010-03-12