Measurement of Mechanical Properties on Plasma Proteins and Computational Simulation of Primary Thrombosis Formation
| Project/Area Number |
20700374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hachinohe National College of Technology |
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Principal Investigator |
MORI Daisuke Hachinohe National College of Technology, 機械工学科, 助教 (50451539)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 一次血栓 / 血漿タンパク分子 / 計算生体力学 |
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| Research Abstract |
We developed a method to analyze platelet adhesion and aggregation computationally, taking into account the distinct properties of two plasma proteins, vonWillebrand factor and fibrinogen. In this method, the hydrodynamic interactions between platelet particles under simple shear flow were simulated using Stokesian dynamics. The binding force between particles mediated by vonWillebrand factor and fibrinogen was modeled.
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Report
(4 results)
Research Products
(4 results)
