Measurement of Mechanical Properties on Plasma Proteins and Computational Simulation of Primary Thrombosis Formation

Research Project

Project/Area Number	20700374
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Biomedical engineering/Biological material science
Research Institution	Hachinohe National College of Technology
Principal Investigator	MORI Daisuke Hachinohe National College of Technology, 機械工学科, 助教 (50451539)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	一次血栓 / 血漿タンパク分子 / 計算生体力学
Research Abstract	We developed a method to analyze platelet adhesion and aggregation computationally, taking into account the distinct properties of two plasma proteins, vonWillebrand factor and fibrinogen. In this method, the hydrodynamic interactions between platelet particles under simple shear flow were simulated using Stokesian dynamics. The binding force between particles mediated by vonWillebrand factor and fibrinogen was modeled.

Report

(4 results)