Analysis of the cytokinesis in terms of mechanics and bio-molecules.
| Project/Area Number |
20700390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MIYOSHI Hiromi The Institute of Physical and Chemical Research, 細胞シミュレーションチーム, 研究員 (50455367)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 細胞変形 / 細胞運動 / 細胞バイオメカニクス / アクチン細胞骨格 / 細胞-マイクロ構造相互作用 / 細胞形態 / メカノバイオロジー / メカノケミカルフィードバック / マイクロ構造化表面 / 力学的摂動 / アクチン / 膜張力 / 細胞極性 / バイオイメージング |
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| Research Abstract |
I have analyzed the spatiotemporal patterns of the cell peripheral activity and the shape, and the relation between the patterns of them. The analysis revealed the mechanism determining the cell peripheral activity and the shape through the mechanochemical feedback ranging from the molecular to the cellular scale. Moreover, the effect of the mechanical perturbation on cells was analyzed by using microstructured surface, which revealed the critical contribution of the mechanical properties of the lamella and cell body for determination of the cell motility and the cell shape.
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Report
(4 results)
Research Products
(11 results)
