Development of biodegradable vascular grafts from salmon skin-derived elastic collagen
| Project/Area Number |
20700393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGAI Nobuhiro Tohoku University, 大学院・医学系研究科, 助教 (30400039)
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| Co-Investigator(Renkei-kenkyūsha) |
MUNEKATA Masanobu 北海道大学, 大学院・工学研究科, 教授 (50261326)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | コラーゲン / 人工血管 / 再生医療 / サケ皮コラーゲン / 組織工学 / 血管再生 / 生体置換 / 抗血栓性 |
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| Research Abstract |
Elastic collagen tubes derived from salmon skin are promising vascular grafts. However, they have some drawbacks such as poor suturability and biodegradability. In this study, we investigated the improvements of mechanical strength and endothelial cell attachment of the collagen tubes by increasing the fibrillar density of collagen matrix, mixing polymers in the collagen matrix, and adsorbing fibronectin on the tubes.
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Report
(4 results)
Research Products
(13 results)
