Preparation of stable supramolecular gene vector in blood and improvement of gene expression efficiency
| Project/Area Number |
20700394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHII Takehiko The University of Tokyo, 大学院・工学系研究科, 助教 (80415075)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 薬物送達システム / 非ウィルス型遺伝子ベクター / PEG / 遺伝子ベクター / ポリイオンコンプレックス / 疎水性相互作用 / 静電相互作用 / 遺伝子治療 / ポリイオンコンブレックス |
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| Research Abstract |
In order to promote the development of safe gene vector, which is desired for gene therapy by systemic administration, we focused on prolonging retention in blood stream of non-viral gene carriers based on synthetic polymer have been studied. As the results, we achieved prolonged blood circulation and enhanced gene expression of the developed gene carrier stabilized by additional hydrophobic functionalization. Furthermore, we tried to cancer gene therapy based on antiangiogenesis strategy, resulting that transplanted and bleeding cancer tissues in mice were significantly suppressed its growth than that of earlier gene carriers.
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Report
(4 results)
Research Products
(28 results)
