| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
In order to promote the development of safe gene vector, which is desired for gene therapy by systemic administration, we focused on prolonging retention in blood stream of non-viral gene carriers based on synthetic polymer have been studied. As the results, we achieved prolonged blood circulation and enhanced gene expression of the developed gene carrier stabilized by additional hydrophobic functionalization. Furthermore, we tried to cancer gene therapy based on antiangiogenesis strategy, resulting that transplanted and bleeding cancer tissues in mice were significantly suppressed its growth than that of earlier gene carriers.
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