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Preparation of novel drug-eluting stents with cell-compatibility and antithrombogenicity

Research Project

Project/Area Number 20700395
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Institute of Technology

Principal Investigator

YOSHIOKA Tomohiko  Tokyo Institute of Technology, 大学院・理工学研究科, 助教 (50452016)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsステント / 金属酸化物 / 表面修飾 / シランカップリング剤 / 金属 / 抗血栓性
Research Abstract

In this study, we focused on surface modification of Ni-free stainless-steel for novel drug-eluting stents with cell-compatibility. Ni-free stainless-steel was heated in order to control the composition of surface oxides. The surface composition was responsible for the immobilization of silane coupling agent, i.e., γ-aminopropyltriethoxysilane (APS). The APS immobilized surface adhered more human umbilical vein endothelial cells than a pristine surface.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Effect of Oxide Layers of Ni-Free Stainless-steel on Silane Coupling Agent Immobilization2009

    • Author(s)
      M. Soya, T. Yoshioka, K. Shinozaki, J. Tanaka
    • Journal Title

      Materials Transactions 50

      Pages: 1318-1321

    • NAID

      10024815722

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Oxide Layers of Ni-Free Stainless-Steel on Silane Coupling Agent Immobilization2009

    • Author(s)
      M.Soya, T.Yoshioka, K.Shinozaki, J.Tanaka
    • Journal Title

      Materials Transactions 50

      Pages: 1318-1321

    • NAID

      10024815722

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] シランカップリング剤固定化に対するNiフリーステンレス鋼表面酸化物の影響2010

    • Author(s)
      征矢大、吉岡朋彦、大森健一、片田康行、田中順三
    • Organizer
      第48回セラミックス基礎科学討論会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Oxidation Process of Ni-Free Fe-Cr-Mo-N System2009

    • Author(s)
      M. Soya, T. Yoshioka, J. Tanaka
    • Organizer
      STAC-3
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Effect of Ni-free Stainless-steel oxide for silane coupling agent immobilization2008

    • Author(s)
      M. Soya, T. Yoshioka, K. Shinozaki, J. Tanaka
    • Organizer
      IUMRS-ICA2008
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Ni-free stainless steel oxide for silane coupling agent immobilization2008

    • Author(s)
      M. Soya, T. Yoshioka, K. Shinozaki and J. Tanaka
    • Organizer
      IUMRS-ICA2008
    • Place of Presentation
      Nagoya Congress Center, Japan
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] シランカップリング剤を用いたNiフリーステンレス鋼表面の修飾2008

    • Author(s)
      征矢大、吉岡朋彦、篠崎和夫、田中順三
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] シランカップリング剤を用いたNiフリーステンレス鋼表面の修飾2008

    • Author(s)
      征矢大、吉岡朋彦、篠崎和夫、田中順三
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] シランカップリング剤固定化に及ぼすNiフリーステンレス鋼表面酸化物の影響2008

    • Author(s)
      征矢大、吉岡朋彦、篠崎和夫、田中順三
    • Organizer
      第24回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      神奈川
    • Year and Date
      2008-07-24
    • Related Report
      2009 Final Research Report
  • [Presentation] シランカップリング剤固定化に及ぼすNiフリーステンレス鋼表面酸化物の影響2008

    • Author(s)
      征矢大、吉岡朋彦、篠崎和夫、田中順三
    • Organizer
      第24回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      神奈川県足柄下郡ホテル花月園
    • Year and Date
      2008-07-24
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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