Development of drug and gene delivery system for injured sites of cardiovascular tissues
| Project/Area Number |
20700396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ISE Hirohiko Tokyo Institute of Technology, フロンティア研究センター, 特任講師 (10324253)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬物輸送システム / N-アセチルグルコサミン / レクチン / 糖鎖高分子 / ビメンチン / デスミン |
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| Research Abstract |
Cardiomyocytes and vascular smooth muscle cells (VSMCs) were found to interact with N-acetylglucosamine (GlcNAc) using glycopolymers containing GlcNAc. It was assumed that these cells have GlcNAc-binding lectin on the cell surfaces. We tried to develop drug and delivery systems for injured site of cardiovascular tissue. The uptake of GlcNAc-conjugated liposomes to cardiomyocytes was observed. These results suggested the development of drug and gene delivery system for injured sites of cardiovascular tissues using GlcNAc-conjugated liposomes.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008
Author(s)
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 117
Pages: 3079-3087
Related Report
Peer Reviewed
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