Application of microfluidics for cell sheet-based tissue engineering

• Project/Area Number: 20700398
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KOBAYASHI Jun Tokyo Women's Medical University, 助教 (20385404)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: バイオマテリアル / 光重合 / 可視光 / マスクレス露光措置 / カンファーキノン / フォトリソグラフィー / フォトリソグラフイー

Research Abstract

Microfluidic hydrogel channels were fabricated by visible-light induced reaction using maskless photolithography device. With maskless photolithography device, micropatterned hydrogel layers were successfully prepared. This technology is useful for generating capillary-like microfluidic channels with engineered tissues.

Research Products

• [Journal Article] Fabrication of a thermoresponsive cell culture dish : a key technology for cell sheet tissue engineering (2010)
  • Author(s): J.Kobayashi, T.Okano
  • Journal Title: Science and Technology of Advanced Materials (accepted)
  • Peer Reviewed
• [Journal Article] Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering (2009)
  • Author(s): Kenichi Nagase, Jun Kobayashi, Teruo Okano
  • Journal Title: Journal of the Royal Society Interface 6
  • Peer Reviewed
• [Journal Article] Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering (2009)
  • Author(s): K. Nagase, J. Kobayashi, T. Okano
  • Journal Title: Journal of the Royal Society Interface (in press)
  • Peer Reviewed
• [Journal Article] Fabrication of a thermoresponsive cell culture dish: a key technology for cell sheet tissue engineering
  • Author(s): Jun Kobayashi, Teruo Okano
  • Journal Title: Science and Technology of Advanced Materials (in press)
  • Peer Reviewed
• [Presentation] 改造液晶プロジェクタによる可視光投影を利用したハイドゲル薄膜のマイクロパターニング (2009)
  • Author(s): 小林純, 糸賀和義, 大和雅之, 岡野光夫
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本
• [Presentation] Surface micropatterning by visible light irradiation with the modified liquid crystal display projector (2009)
  • Author(s): Jun Kobayashi, Kazuyoshi Itoga, Masayuki Yamato, Teruo Okano
  • Organizer: 第58回高分子学会年次大会
  • Place of Presentation: 神戸
• [Presentation] Surface micropatterning of hydrophilic polymers by visible light irradiation (2009)
  • Author(s): Jun Kobayashi, Kazuyoshi Itoga, Masayuki Yamato, Teruo Okano
  • Organizer: 8th International Symposium on Frontiers in Biomedical Polymers
  • Place of Presentation: 三島
• [Presentation] Surface micropatterning of hydrophilic polymers by visible light irradiation (2009)
  • Author(s): J.Kobayashi, K.Itoga, M.Yamato, T.Okano
  • Organizer: 8th International Symposium on Frontiers in Biomedical Polymers
  • Place of Presentation: 東レ総合研修センター(静岡県)
• [Presentation] Surface micropatterning by visible light irradiation with the modified liquid crystal display projector (2009)
  • Author(s): J.Kobayashi, K.Itoga, M.Yamato, T.Okano
  • Organizer: 第58回高分子学会年次大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] 改造液晶プロジェクタによる可視光投影を利用したハイドゲル薄膜のマイクロパターニング (2009)
  • Author(s): 小林純, 糸賀和義, 大和雅之, 岡野光夫
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学(熊本県)