Development of a nanocarrier that can change its character responding to a tumor environment

• Project/Area Number: 20700400
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: 公益財団法人がん研究会 (2011); Japanese Foundation For Cancer Research (2008-2010)
• Principal Investigator: MATSUMURA Sachiko 公益財団法人がん研究会, がん研究所蛋白創製研究部, 研究員 (90414052)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ドラッグデリバリー / ナノ粒子 / ペプチド / がん / 環境応答性 / マトリックスメタロプロテアーゼ / カーボンナノチューブ / フェリチン / カーボンナノ粒子

Research Abstract

Nanoparticles are fascinating as a carrier for drugs and imaging agents. In this study, nanoparticles having responsivity to a tumor environment are constructed. Upon sensing an activity of enzyme, which is highly expressed in many types of tumors, the nanoparticles can obtain the ability to enter cells. Two kinds of nanoparticles, that is carbon-or protein-based ones, are studied.

Research Products

• [Journal Article] Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer (2009)
  • Author(s): Matsumura S, Sato S, Yudasaka M, Tomida A, Tsuruo T, Iijima S, Shiba K
  • Journal Title: Molecular Pharmaceutics Volume: 6(2) Issue: 2 Pages: 441-447
  • DOI: 10.1021/mp800141v
  • Peer Reviewed
• [Journal Article] Prevention of carbon nanoborn agglomeration using a conjugate composed of comb-shaped polvethvlene glycol and a peptide aptamer (2009)
  • Author(s): Matsumura S, Sato S, Yudasaka M, Tomida A, Tsuruo T, Iijima S, Shiba K.
  • Journal Title: Molecular Pharmaceutics 6(2) Pages: 441-447
  • Peer Reviewed
• [Presentation] Bioapplication of the surface modified carbon nanohorns for drug delivery systems (2009)
  • Author(s): Matsumura S, Miyawaki J, Yuge R, Sato S, Tomida A, Tsuruo T, Yudasaka M, Iijima S, Shiba K
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-06-20
• [Presentation] Bioapplication of the surface modified carbon nanohorns for drug delivery systems (2009)
  • Author(s): Matsumura S, Miyawaki J, Yuge R, Sato, S, Tomida A, Tsuruo T, Yudasaka M, Iijima S, Shiba K
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-20
• [Presentation] PEG-ペプチド複合体によるカーボンナノホーンの分散化効果と肺への蓄積 (2008)
  • Author(s): 松村幸子、佐藤重男、湯田坂雅子、冨田章弘、鶴尾隆、飯島澄男、芝清隆
  • Organizer: 第35回記念フラーレン・ナノチューブ総合シンポジウム
  • Place of Presentation: 東京工業大学大岡山キャンパス(東京)
  • Year and Date: 2008-08-28
• [Presentation] PEG-ペプチド複合体によるカーボンナノホーンの分散化効果と肺への蓄積 (2008)
  • Author(s): 松村 幸子、佐藤 重男、湯田坂雅子、冨田 章弘、鶴尾 隆、飯島澄男、芝 清隆
  • Organizer: 第35回記念フラーレン・ナノチューブ総合シンポジウム
  • Place of Presentation: 東京工業大学 大岡山キャンパス
  • Year and Date: 2008-08-28
• [Presentation] 体内投与のためのカーボンナノホーンの分散化の検討 (2008)
  • Author(s): 松村幸子、湯田坂雅子、飯島澄男、芝清隆
  • Organizer: 第24回日本DDS学会学術集会
  • Place of Presentation: 六本木アカデミーヒルズ40(東京)
  • Year and Date: 2008-06-29
• [Presentation] 体内投与のためのカーボンナノホーンの分散化の検討 (2008)
  • Author(s): 松村幸子、湯田坂雅子、飯島澄男、芝清隆
  • Organizer: 第24会日本DDS学会学術集会
  • Place of Presentation: 六本木アカデミーヒルズ40(東京)
  • Year and Date: 2008-06-29