Development of Brain-Machine Interface model by using analysis of EEG and rTMS

• Project/Area Number: 20700420
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hokkaido University
• Principal Investigator: TAKEUCHI Naoyuki Hokkaido University, 北海道大学病院, 医員 (10374498)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: リハビリテーション / 脳卒中 / 経頭蓋磁気刺激

Research Abstract

We had developed the therapy of hemiparesis after stroke by using repetitive transcranial magnetic stimulation that induced the reorganization due to the reduction of inhibitory function. The neurophysiological study had revealed that the weak inhibitory function in stroke patients with good motor function facilitated the reorganization of ipsilesional primary motor cortex and the transcallosal inhibition from the contralesional to the ipsilesional motor cortex had correlated with the mirror activity. The study of the electroencephalogram coherence after rTMS had indicated that the combination of rTMS and Brain-Machine Interface was important for stroke therapy.

Research Products

• [Journal Article] Correlation of motor function with transcallosal and intracortical inhibition after stroke. (2010)
  • Author(s): Takeuchi N, Tada T, Toshima M, Ikoma K.
  • Journal Title: J Rehabil Med. 42(10) Pages: 962-966
  • Peer Reviewed
• [Journal Article] 経頭蓋磁気刺激を用いた脳卒中リハビリテーション (2010)
  • Author(s): 竹内直行, 生駒一憲
  • Journal Title: 臨床脳波 52巻9号 Pages: 529-533
• [Journal Article] Correlation of motor function with transcallosal and intracortical inhibition after stroke (2010)
  • Author(s): Takeuchi N, et al.
  • Journal Title: J Rehabil Med. Volume: 42 Pages: 962-966
  • Peer Reviewed
• [Journal Article] 経頭蓋磁気刺激を用いた脳卒中リハビリテーション(1) (2010)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: 臨床脳波 Volume: 52 Pages: 529-533
  • NAID: 40017281154
• [Journal Article] 経頭蓋磁気刺激を用いた脳卒中リハビリテーション(2) (2010)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: 臨床脳波 Volume: 52 Pages: 596-601
  • NAID: 40017328826
• [Journal Article] Repetitive transcranial magnetic stimulation over bilateral hemispheres enhances motor function and training effect of paretic hand in patients after stroke. (2009)
  • Author(s): Takeuchi N, Tada T, Toshima M, Matsuo Y, Ikoma, K.
  • Journal Title: J Rehabil Med. 41(13) Pages: 1049-1054
  • Peer Reviewed
• [Journal Article] リハビリテーションのトピックス:経頭蓋磁気刺激療法 (2009)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: Clinical Neuroscience 27巻9号 Pages: 1058-1060
• [Journal Article] 磁気刺激による治療 (2009)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: 総合リハビリテーション 37巻8号 Pages: 705-709
• [Journal Article] Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke. (2008)
  • Author(s): Takeuchi N, Tada T, Toshima M, Chuma T, Matsuo Y,Ikama K.
  • Journal Title: J Rehabil Med. 40(4) Pages: 298-303
  • Peer Reviewed
• [Journal Article] Repetitive transcranial magnetic stimulation of the unaffected hemisphere in a patient who was forced to use the affected hand. (2008)
  • Author(s): Takeuchi N, Toshima M, Chuma T, Matsuo Y, Ikoma, K.
  • Journal Title: Am J Phys Med Rehabil. 87(1) Pages: 74-77
  • Peer Reviewed
• [Journal Article] 健常側拘束によるリハビリテーション:Constraint-inducedmovement therapy (2008)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: Clinical Neuroscience 26巻11号 Pages: 1286-1287
• [Journal Article] 最新のリハビリテーション:脳卒中と経頭蓋磁気刺激 (2008)
  • Author(s): 竹内直行
  • Journal Title: リハビリテーション医学 45巻9号 Pages: 598-604
  • NAID: 110006935725
• [Journal Article] 最新のリハビリテーション : 脳卒中と経頭蓋磁気刺激 (2008)
  • Author(s): 竹内直行
  • Journal Title: リハビリテーション医学 45 Pages: 1225-1231
  • NAID: 110006935725
• [Journal Article] 健常側拘束によるリハビリテーション : Constraint-induced movement therapy (2008)
  • Author(s): 竹内直行、生駒一憲
  • Journal Title: Clinical Neuroscience 26 Pages: 1286-1287
• [Presentation] 1 Hz rTMS over unaffected hemisphere in stroke patients alters bilateral movements and coupling between motor areas. (2010)
  • Author(s): Takeuchi N, Ikoma K.
  • Organizer: 29^<th> International congress of clinical neurophysiology.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-11-01
• [Presentation] Therapeutic application of repetitive transcranial magnetic stimulation in motor recovery after stroke. (2010)
  • Author(s): Takeuchi N
  • Organizer: The 3^<rd> Pan Pacific Symposium on Stem Cell Research.
  • Place of Presentation: Taichung, Taiwan
  • Year and Date: 2010-04-14
• [Presentation] Therapeutic application of repetitive transcranial magnetic stimulation in motor recovery after stroke (2010)
  • Author(s): Takeuchi N.
  • Organizer: The 3^<rd> Pan Pacific Symposium on Stem Cell Research.
  • Place of Presentation: Taichung, Taiwan
  • Year and Date: 2010-04-14
• [Presentation] 脳卒中後運動麻痺の病態理解と治療における経頭蓋磁気刺激の応用 (2009)
  • Author(s): 竹内直行
  • Organizer: オーガナイズドセッション3第48回日本生体医工学大会
  • Place of Presentation: 東京,日本
  • Year and Date: 2009-04-23
• [Presentation] 脳卒中に対する反復経頭蓋磁気刺激治療 (2008)
  • Author(s): 竹内直行
  • Organizer: 第19回磁気刺激法の臨床応用と安全性に関する研究会
  • Place of Presentation: 神戸,日本
  • Year and Date: 2008-11-12
• [Presentation] 脳卒中に対する反復経頭蓋磁気刺激治療 (2008)
  • Author(s): 竹内直行、中馬孝容、生駒一憲
  • Organizer: 磁気刺激法の臨床応用と安全性に関する研究会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-11-12
• [Book] 脳の可塑性へのアプローチ.リハ医とコメディカルのための最新リハビリテーション医学(第6章脳の可塑性へのアプローチ1運動麻痺に対する経頭蓋磁気刺激) (2010)
  • Author(s): 上月正博, ら編集
  • Publisher: 先端医療技術研究所
• [Book] 脳の可塑性へのアプローチ.リハ医とコメディカルのための最新リハビリテーション医学.第6章脳の可塑性へのアプローチ1運動麻痺に対する経頭蓋磁気刺激 (2010)
  • Author(s): 上月正博, ら編集
  • Publisher: 先端医療技術研究所