Elucidation of the role of nitric oxide system in cardiac rehabilitation

• Project/Area Number: 20700422
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO Daisuke Tohoku University, 病院, 理学療法士 (50466570)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: リハビリテーション医学 / 心臓リハビリテーション / Nitric Oxide / Nitric Oxide Synthase / 心筋梗塞 / 心臓 / 腎臓 / 運動 / NO / NOS

Research Abstract

I examine the effects of the exercise training on nitric oxide(NO)system in chronic heart failure(CHF)model of rats. Exercise improved cardiac and renal function, and increased the expression of endothelial nitric oxide synthase(eNOS)and neuronal NOS(nNOS)in left ventricle and kidney of CHF rats. These findings suggest that the upregulation of the renal NO system may be a novel mechanism that could explain the beneficial effects of exercise training.

Research Products

• [Journal Article] Endogenous hydrogen peroxide upregulates the expression of NO synthases in the kidney of SHR. (2011)
  • Author(s): Cao P, Ito O, Guo Q, Ito D, Muroya Y, Rong R, Mori T, Ito S, Kohzuki M.
  • Journal Title: Journal of Hypertension Volume: (未定 印刷中)
  • Peer Reviewed
• [Journal Article] Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats. (2010)
  • Author(s): Ito D, Ito O, Mori N, Muroya Y, Cao P, Takashima K, Kanazawa M, Kohzuki M.
  • Journal Title: Journal of Hypertension Volume: 28 Pages: 2278-2288
  • Peer Reviewed
• [Journal Article] 高血圧自然発症ラットの腎Rhoキナーゼへの atorvastatin の効果 (2009)
  • Author(s): 伊藤大亮
  • Journal Title: Therapeutic Research 30 Pages: 1427-1428
  • Peer Reviewed
• [Journal Article] 高血圧自然発症ラットの血圧と腎 nitric oxide 合成酵素に対する atorvastatin 長期投与の効果 (2009)
  • Author(s): 伊藤大亮
  • Journal Title: 東北医誌 121 Pages: 66-67
  • NAID: 10026082893
• [Presentation] 慢性心不全ラットにおける心・腎nitric oxide合成酵素に対する長期的運動の影響 (2011)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2011-02-04
• [Presentation] 慢性心不全ラットにおける心・腎nitric oxide合成酵素に対する長期的運動の影響 (2011)
  • Author(s): 伊藤大亮
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: かがわ国際会議場(高松)
  • Year and Date: 2011-02-04
• [Presentation] 慢性心不全ラットの血圧と心・腎nitric oxide合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] 慢性心不全ラットの血圧と心・腎nitric oxide合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-16
• [Presentation] Effects of exercise training on nitric oxide synthases in rats with chronic heart failure. (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M.
  • Organizer: 23rd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Vancouver
  • Year and Date: 2010-09-28
• [Presentation] Effects of exercise training on nitric oxide synthases in rats with chronic heart failure. (2010)
  • Author(s): Daisuke Ito
  • Organizer: 23rd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2010-09-28
• [Presentation] 慢性心不全モデルラットの心・腎NO合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第35回日本運動療法学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-07-03
• [Presentation] 慢性心不全モデルラットの心・腎NO合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮
  • Organizer: 第35回日本運動療法学会
  • Place of Presentation: 東北大学医学部艮陵会館(仙台)
  • Year and Date: 2010-07-03
• [Presentation] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Kohzuki M.
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications on Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-18
• [Presentation] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. (2010)
  • Author(s): Daisuke Ito
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications on Nitric Oxide
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-06-18
• [Presentation] Disability prevention of cardiovascular and chronic kidney diseases : Effect of a combination therapy with exercise training and atorvastatin on blood pressure and nitric oxide synthase in spontaneously hypertensive rats (2009)
  • Author(s): 伊藤大亮
  • Organizer: 5th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: イスタンブール(トルコ)
  • Year and Date: 2009-06-14
• [Presentation] Effect of chronic treatment with atorvastatin on nitric oxide synthase, Rho-kinase and Akt in the kidney of spontaneously hypertensive rats (2009)
  • Author(s): 伊藤大亮
  • Organizer: 10^<th> International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: ホテル松島大観荘(宮城県)
  • Year and Date: 2009-06-03
• [Presentation] 高血圧自然発症ラットの腎NO合成酵素に対する atorvastatin 長期投与の効果 (2009)
  • Author(s): 伊藤大亮
  • Organizer: 第9回日本NO学会
  • Place of Presentation: グランシップ(静岡県)
  • Year and Date: 2009-05-09
• [Presentation] 高血圧自然発症ラットの腎Rhoキナーゼへのatorvastatin長期投与の効果. (2009)
  • Author(s): 伊藤大亮
  • Organizer: 第21回腎と脂質研究会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-03-28
• [Presentation] 高血圧自然発症ラットの血圧と腎NO合成酵素に対する長期的運動とatorvastatin併用の効果 (2009)
  • Author(s): 伊藤大亮
  • Organizer: 第25回日本リハビリテーション医学会東北地方会
  • Place of Presentation: 山形市
  • Year and Date: 2009-02-28
• [Presentation] 高血圧自然発症ラットの血圧と腎nitric oxide合成酵素に対する長期.的運動の影響. (2008)
  • Author(s): 伊藤大亮
  • Organizer: 第31回日本高血圧学会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-10-10
• [Presentation] Atorvastatin prevents development of hypertension with upregul ation of renal expression of endothelial and neuronal nitric o xide synthases in spontaneously hypertensive rats. (2008)
  • Author(s): Ito D
  • Organizer: American Heart Association 62nd High Blood Pressure Research Conference
  • Place of Presentation: Atlanta (アメリカ)
  • Year and Date: 2008-09-19
• [Presentation] Chronic exercise prevents development of hypertension with upr egulation of nitric oxide synthases in spontaneously hypertens ive rats. (2008)
  • Author(s): Ito D
  • Organizer: 10th International Congress of the Asian Co nfederation for Physical Therapy
  • Place of Presentation: Chiba
  • Year and Date: 2008-08-30
• [Presentation] Atorvastatin prevents development of hypertension with upregul ation of nitric oxide synthases through phosphor-Akt pathway i n spontaneously hypertensive rats. (2008)
  • Author(s): Ito D
  • Organizer: 22nd Scientific Meeting of International So ciety of Hypertension
  • Place of Presentation: Berlin(ドイツ)
  • Year and Date: 2008-06-19
• [Presentation] 高血圧自然発症ラットにお.けるatorvastatinの腎NO合成酵素およびAktリン.酸化への効果 (2008)
  • Author(s): 伊藤大亮
  • Organizer: 第51回日本腎臓学会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-05-30