Distribution and development of the proton-gated ion channel in respiratory system

• Project/Area Number: 20700429
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Sapporo Medical University
• Principal Investigator: KIKUCHI Shin Sapporo Medical University, 医学部, 助教 (20404585)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ASIC2 / 線毛 / 呼吸器 / 発生 / 有毛細胞 / 鼻中隔 / 免疫組織化学 / イオンチャンネル

Research Abstract

Acid sensing ion channel 2 (ASIC2) is a member of epithelial sodium channels and works in low pH. Our study revealed that ASIC2 expressed at respiratory cilia and the expression was observed during fetus period in rat. These results suggested that respiratory ciliated cells had ability to sense an acidic environment in airway from the birth.

Research Products

• [Journal Article] Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. (2009)
  • Author(s): Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N
  • Journal Title: Med. Mol. Morpho. 42 Pages: 204-211
  • NAID: 10027269508
  • Peer Reviewed
• [Journal Article] Apratacin遺伝子変異(689insT)が認められた眼球運動執行を伴う失調症(Ataxiaoculomotor apraxia ; AOA1)患者の臨床症状 (2009)
  • Author(s): 堀本佳誉, 他
  • Journal Title: 理学療法学 36 Pages: 317-323
  • Peer Reviewed
• [Journal Article] Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro (2009)
  • Author(s): Ohkuni T, et al.
  • Journal Title: Med.Mol.Morpho. 42 Pages: 204-211
  • Peer Reviewed
• [Journal Article] Expression of ASIC2 in ciliated cells and stereociliated cells. (2008)
  • Author(s): Kikuchi S, Ninomiya T, Kawamata T, Tatsumi H
  • Journal Title: Cell Tissue Res 333 Pages: 217-224
  • Peer Reviewed
• [Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro. (2008)
  • Author(s): Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
  • Journal Title: J. Mol. Histol 39 Pages: 265-273
  • Peer Reviewed
• [Journal Article] The change of grip strength in a patient with congenital myotonic dystrophy over a 4-year period. (2008)
  • Author(s): Kikuchi S, Kozuka N, Uchida E, Ninomiya T, Tatsumi H, Takeda H, Tachi N
  • Journal Title: J. Jpn. Phys. Ther. Assoc. 11 Pages: 23-27
  • NAID: 130004677670
  • Peer Reviewed
• [Journal Article] Expression of ASIC2 in ciliated cells and stereociliated cells (2008)
  • Author(s): Kikuchi S
  • Journal Title: Cell Tissue Res 333(2) Pages: 217-224
  • Peer Reviewed
• [Journal Article] The change of grip strength in a patient with congenital myotonic dystrophy over a 4-year (2008)
  • Author(s): Kikuchi S
  • Journal Title: J. Jpn. Phys. Ther. Assoc 11(1) Pages: 23-27
  • Peer Reviewed
• [Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro (2008)
  • Author(s): Takano K
  • Journal Title: J. Mol. Histol 39(3) Pages: 265-273
  • Peer Reviewed
• [Presentation] マウス末梢性髄鞘におけるtricellulinの発現 (2010)
  • Author(s): 菊池真, 他
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 盛岡市(岩手県)
  • Year and Date: 2010-03-28
• [Presentation] マウス末梢髄鞘におけるtricellulinの発現 (2010)
  • Author(s): 菊池真, 二宮孝文, 小島隆, 辰巳治之
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 盛岡市(岩手)
• [Presentation] 脊髄神経根におけるMyelin Protein Zeroの発現:神経根と脊髄移行部における微細構造の観察 (2010)
  • Author(s): 二宮孝文, 菊池真, 舘延忠, 辰巳治之
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 盛岡市(岩手)
• [Presentation] 胎生期ラット鼻中隔上皮線毛細胞におけるASIC2の発現 (2009)
  • Author(s): 菊池真
  • Organizer: 第114回日本解剖学会総会
  • Place of Presentation: 岡山市(岡山県)
  • Year and Date: 2009-03-30
• [Presentation] 胎生期ラット鼻中隔上皮線毛細胞におけるASIC2の発現 (2009)
  • Author(s): 菊池真, 二宮孝文, 市川量一, 新見隆彦, 辰巳治之
  • Organizer: 第114回日本解剖学会総会
  • Place of Presentation: 岡山市(岡山)
• [Presentation] 脊髄神経根におけるMyelin Protein Zero (MPZ)の発現と神経線維の形態的特徴 (2009)
  • Author(s): 二宮孝文, 菊池真, 新見隆彦, 市川量一, 辰巳治之
  • Organizer: 第114回日本解剖学会総会
  • Place of Presentation: 岡山市(岡山)
• [Presentation] 登上線維を除去した場合における小脳プルキンエ細胞の樹状突起のシナプス構築の発生過程 (2009)
  • Author(s): 市川量一, 菊池真, 新見隆彦, 二宮孝文, 辰巳治之, 渡辺雅彦
  • Organizer: 第114回日本解剖学会総会
  • Place of Presentation: 岡山市(岡山)
• [Presentation] 変異aprataxin導入培養ラット末梢神経における髄鞘形成 (2008)
  • Author(s): 堀本佳誉, 菊池真, 小塚直樹, 舘延忠
  • Organizer: 第50回小児神経学会総会
  • Place of Presentation: 港区(東京)
• [Presentation] 眼球運動失行を伴う失調症患者(689insT)の臨床症状 (2008)
  • Author(s): 堀本佳誉, 菊池真, 小塚直樹, 舘延忠
  • Organizer: 第43回日本理学療法学術大会
  • Place of Presentation: 博多市(福岡)