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Effects of AMP kinase and nitric oxide synthase on skeketal muscle SIRT1 expression

Research Project

Project/Area Number 20700524
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionTohoku Institute of Technology

Principal Investigator

SUWA Masataka  Tohoku Institute of Technology, ライフデザイン学部, 講師 (50464392)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords一酸化窒素合成酵素 / SIRT1 / 骨格筋 / ミトコンドリア生合成 / 持久的トレーニング
Research Abstract

To estimate the role of AMP-activated protein kinase and nitric oxide synthase on skeletal muscle SIRT1 protein expression, we treated AMP-activated protein kinase activator or nitric oxide synthase inhibitor to rats. The results might suggest that the both of AMP-activated protein kinase and nitric oxide synthase positively regulate the SIRT1 expression in skeletal muscle.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Short-term adenosine monophosphate- activated protein kinase activator 5-aminoimidazole-4-carboxamide-1- β-d-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle.

    • Author(s)
      Suwa M, Nakano H, Radak Z, Kumagai S
    • Journal Title

      Metabolism (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increasea the sirtuin 1 protein expression in skeletal muscle

    • Author(s)
      Masataka Suwa, Hiroshi Nakano, Zsolt Radak, Shuzo Kumagai
    • Journal Title

      Metabolism (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 一酸化窒素合成酵素阻害による骨格筋の代謝特性と組織化学的特性の変化.2009

    • Author(s)
      諏訪雅貴、中野裕史、熊谷秋三
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 一酸化窒素合成酵素阻害による骨格筋の代謝特性と組織化学的特性の変化2009

    • Author(s)
      諏訪雅貴、中野裕史、熊谷秋三
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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