| Project/Area Number |
20700525
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Kyoto Prefectural University |
|---|
Principal Investigator |
AOI Wataru Kyoto Prefectural University, 生命環境科学研究科, 助教 (60405272)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 骨格筋 / エネルギー代謝 / 加齢 / 酸化ストレス / プロテオミクス / 蛋白質翻訳後修飾 |
|---|
| Research Abstract |
c57BL/6 mice kept with free access to chow and sedentary to old age show lipid accumulation and impairment of glucose tolerance as well as oxidative damage in skeletal muscle. In this study, we investigated oxidative protein modification in skeletal muscle associated with impairment of energy metabolism using the animal model as a model of glucose metabolism disorder. Consequently, it has been shown that nitration of tyrosine residues in adenylate kinase 1, which regulates intracellular AMP content, was increased. This may lead to the impairment of glucose uptake in skeletal muscle via lower activity of AMP-activated protein kinase in old mice.
|
