Identification of novel exercise-specific factors in adipocytes
Project/Area Number |
20700527
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Sports science
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Research Institution | Kyorin University |
Principal Investigator |
SAKURAI Takuya Kyorin University, 医学部, 助教 (20353477)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 運動トレーニング / 脂肪組織 / DNAアレイ / Nox2 / 細胞外マトリックス / 脂肪組織由来幹細胞 / 脂肪細胞分化 / 網羅的遺伝子発現解析 / ペルオキシソーム増殖剤応答性受容体γ / hypoxia-inducible factor-1α / Sfr2 / Prps2 / 酸化ストレス |
Research Abstract |
In the present study, DNA array analysis was performed to identify novel genes whose expression was changed in white adipose tissue (WAT) by exercise training (TR) Expression of genes for extracellular matrix-related factors, such as collagen, and NOX2, the catalytic subunit of NADPH oxidase, in WAT was changed by TR. Moreover, TR affected the expression of adipocyte differentiation-related genes in adipose tissue-derived stem cells.
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Report
(3 results)
Research Products
(85 results)
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[Journal Article] Hypoxia-inducible factor-1αsuppresses the expression of macrophage scavenger receptor 1.2010
Author(s)
Shirato K, Kizaki T, Sakurai T, Ogasawara J, Ishibashi Y, Iijima T, Okada C, Noguchi I, Imaizumi K, Taniguchi N, Ohno H
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Journal Title
Pflugers Arch 459
Pages: 93-103
Related Report
Peer Reviewed
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[Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway.2009
Author(s)
Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, Kizaki T, Izawa T, Ishida H, Ohno H
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Journal Title
Phytother Res 23
Pages: 1626-1633
Related Report
Peer Reviewed
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[Journal Article] The supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, has a positive effect on fatigue during regular track- and- field training in young athletes.2008
Author(s)
Ohno H, Sakurai T, Hisajima T, Abe S, Kizaki T, Ogasawara J, Ishibashi Y, Imaizumi K, Takemasa T, Haga S, Kitadate K, Nishioka H, Fujii H
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Journal Title
Adv Exerc Sports Physiol 13
Pages: 93-99
NAID
Related Report
Peer Reviewed
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[Journal Article] 新規低分子化ポリフェノールOligonolの抗酸化作用2008
Author(s)
櫻井拓也, 北舘健太郎, 西岡浩, 藤井創, 久島達也, 安部茂, 木崎節子, 小笠原準悦, 白土健, 石橋義永, 井澤鉄也, 今泉和彦, 鈴木健二, 中野法彦, 大野秀樹
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Journal Title
Food Function 5
Pages: 2-11
NAID
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[Presentation] The signal transduction pathway of Oligonol-induced phosphorylation on ERK1/2 in primary rat adipocytes.2009
Author(s)
Ogasawara J, Kitadate K, Nishioka H, Wakame K, Fujii H, Sakurai T, Kizaki T, Maegawa T, IshibashiY, Izawa T, Saitoh D, Ohno H
Organizer
17th International Symposium of AHCC Research Association
Place of Presentation
Sapporo
Related Report
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[Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue.2009
Author(s)
Sakurai T, Kitadate K, Wakame K, Nishioka H, Fujii H, Hisajima T, Abe S, Kizaki T, Ogasawara J, IshibashiY, Shirato K, Imaizumi K, Ohno H
Organizer
3rd Symposium International Nutrition, Oxygen Biology and Medicine
Place of Presentation
Paris
Related Report
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[Presentation] β作動性脂質代謝とユビキチン2008
Author(s)
小笠原準悦, 櫻井拓也, 白土健, 木崎節子, 今泉和彦, 井澤鉄也, 大野秀樹
Organizer
第1回脳・神経・内分泌から運動の意義を考える会
Place of Presentation
別府
Year and Date
2008-09-17
Related Report
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[Presentation] Effect of Oligonol on lipolysis in primary rat adipocytes.2008
Author(s)
Ogasawara J, Sakurai T, Kitadate K, Nishioka H, Fujii H, Shirato K, IshibashiY, Kizaki T, Izawa T, Saitoh D, Imaizumi K, Ohno H
Organizer
Functional Polyphenol Symposium ~ Novel Use of Low Molecular Polyphenol: Oligonol
Place of Presentation
Sapporo
Year and Date
2008-07-25
Related Report
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[Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞への分化を抑制する2008
Author(s)
櫻井拓也, 井澤鉄也, 木崎節子, 小笠原準悦, 白土健, 石橋義永, 今泉和彦, 武政 徹, 長澤純一, 芳賀脩光, 大野秀樹
Organizer
第6回日本予防医学会学術総会
Place of Presentation
東京
Related Report
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[Presentation] ライチ由来新規低分子化ポリフェノールOligonolは疲労改善効果をもつ2008
Author(s)
櫻井拓也, 北舘健太郎, 西岡浩, 藤井創, 久島達也, 安部茂, 木崎節子, 小笠原準悦, 白土健, 石橋義永, 井澤鉄也, 今泉和彦, 石田均, 大野秀樹
Organizer
国際食品機能学会2008
Place of Presentation
東京
Related Report
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