The induction of autophagy and exercise effect in age-related muscle atrophy.
| Project/Area Number |
20700531
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Waseda University |
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Principal Investigator |
OGATA Tomonori Waseda University, 総合研究機構, 助手 (30434343)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAOKA Isao 早稲田大学, スポーツ科学学術院, 教授 (80112712)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老齢性筋萎縮 / オートファジー / 小胞体ストレス / 骨格筋 / 運動 / 筋萎縮 |
|---|
| Research Abstract |
Purpose of this study was to examine the induction and signal transduction of autophagy in age-related muscle atrophy. This study showed the activations of ER stress signal which induced by accumulation of denature protein, in aged-rat skeletal muscle. However, LC3-II, macroautophagy marker protein, was no change in aged muscle. On the other hand, prolonged exercise training was no effect on LC3-II expression level.
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Report
(3 results)
Research Products
(9 results)
