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Anti-fatigue effects of intrinsic motivation using non-invasive functional neuroimaging

Research Project

Project/Area Number 20700541
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionOsaka City University

Principal Investigator

MIZUNO Kei  Osaka City University, 大学院・医学研究科, 研究員 (60464616)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心身の健康 / 疲労 / 意欲 / 内発的意欲 / パフォーマンス / fMRI / 脳機能イメージング
Research Abstract

Fatigue sensation was attenuated by an intrinsic reward (IR) during a fatigue-inducing tasks. Functional magnetic resonance imaging revealed that the brain regions involved in the IR were ventral striatum (VS) and anterior cingulate cortex (ACC) during the fatigue-inducing tasks. In addition, the activations of the VS and ACC were correlated with motivation score and score for the alleviation of fatigue sensation as derived from a questionnaire, respectively. These results suggest that anti-fatigue effects of intrinsic motivation are associated with the responsiveness of the ACC.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009 2008

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (24 results) Book (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Relationship between cognitive function and prevalence of decrease in intrinsicacademic motivation in adolescents.2011

    • Author(s)
      Mizuno Kei
    • Journal Title

      Behavioral and Brain Functions

      Volume: 7 Pages: 4-4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome-A6-month follow-up study.2011

    • Author(s)
      Kawatani Junko, Mizuno Kei
    • Journal Title

      Brain & Development

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in cognitive functions of students in the transitional period from elementary school to junior high school.2011

    • Author(s)
      Mizuno Kei
    • Journal Title

      Brain & Development

      Volume: (in press)

    • NAID

      10029561733

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students.2011

    • Author(s)
      Mizuno Kei
    • Journal Title

      Brain & Development

      Volume: (in press)

    • NAID

      10029561992

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality and fatigue in medical students.2010

    • Author(s)
      Tanaka, M., Mizuno, K., Fukuda, S., Watanabe, Y.
    • Journal Title

      Psychological Reports 106(2)

      Pages: 567-575

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effort-reward imbalance for learning is associated with fatigue in school children.2010

    • Author(s)
      Fukuda Sanae, Mizuno Kei
    • Journal Title

      Behavioral Medicine

      Volume: 36 Pages: 53-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality and fatigue in medical students.2010

    • Author(s)
      Tanaka Masaaki, Mizuno Kei
    • Journal Title

      Psychological Reports

      Volume: 106 Pages: 567-575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperament and character as predictors of fatigue-induced symptoms among school children in Japan : A 1-year follow-up study.2010

    • Author(s)
      Yamano Emi, Mizuno Kei
    • Journal Title

      Comprehensive Psychiatry

      Volume: 51 Pages: 256-265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of mild-stream bathing on recovery from mental fatigue.2010

    • Author(s)
      Mizuno Kei
    • Journal Title

      Medical Science Monitor 16(CR)

      Pages: 8-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperament and character as predictors of fatigue-induced symptoms among school children in Japan : A 1-year follow-up study.2010

    • Author(s)
      Yamano Emi, Mizuno Kei
    • Journal Title

      Comprehensive Psychiatry (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality and fatigue in medical students.2010

    • Author(s)
      Tanaka Masaaki, Mizuno Kei
    • Journal Title

      Psychological Reports (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effort-reward imbalance for learning is associated with fatigue in school children.2010

    • Author(s)
      Fukuda Sanae, Mizuno Kei
    • Journal Title

      Behavioral Medicine (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central nervous system fatigue alters autonomic nerve activity.2009

    • Author(s)
      Tanaka, M., Mizuno, K., Tajima, S., Sasabe, T., Watanabe, Y.
    • Journal Title

      Life Sciences 84(7-8)

      Pages: 233-299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Personality traits associated with intrinsic academic motivation in medical students.2009

    • Author(s)
      Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., Tajima, S., Watanabe, Y.
    • Journal Title

      Medical Education 43(4)

      Pages: 384-387

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress and coping style are associated with severe fatigue in medical students.2009

    • Author(s)
      Tanaka, M., Fukuda, S., Mizuno, K., Kuratsune, H., Watanabe, Y.
    • Journal Title

      Behavioral Medicine 35(3)

      Pages: 87-92

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mental and physical fatigue-related biochemical alterations.2009

    • Author(s)
      Nozaki Satoshi, Mizuno Kei
    • Journal Title

      Nutrition 25

      Pages: 51-57

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress and coping style are associated with severe fatigue in medical students.2009

    • Author(s)
      Tanaka Masaaki, Mizuno Kei
    • Journal Title

      Behavioral Medicine 35

      Pages: 87-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in plasma and tissue amino acid levels in an animal model of complex fatigue.2009

    • Author(s)
      Jin Guanghua, Mizuno Kei
    • Journal Title

      Nutrition 25

      Pages: 597-607

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily oral administration of crocetin attenuates physical fatigue in human.2009

    • Author(s)
      Mizuma Hiroshi, Mizuno Kei
    • Journal Title

      Nutrition Research 29

      Pages: 145-150

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats.2009

    • Author(s)
      Nozaki Satoshi, Mizuno Kei
    • Journal Title

      Nutrition Research 29

      Pages: 867-872

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] テアニン高含有緑茶抹摂取による高齢者の認知症予防効果.2009

    • Author(s)
      片岡洋祐、水野敬
    • Journal Title

      日本未病システム学会雑誌 15

      Pages: 17-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central nervous system fatigue alters autonomic nerve activity2009

    • Author(s)
      Tanaka Masaaki
    • Journal Title

      Life Sciences 84

      Pages: 235-239

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality traits associated with intrinsic academic motivation in medical students2009

    • Author(s)
      Tanaka Masaaki
    • Journal Title

      Medical Education 43

      Pages: 384-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress and coping style are associated with severe fatigue in medical students2009

    • Author(s)
      Tanaka Masaaki
    • Journal Title

      Behavioral Medicine (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategies specifically designed for supporting the academic motivation of individual college students.2008

    • Author(s)
      Yoshida, M., Tanaka, M., Mizuno, K., Ishii, A., Nozaki, K., Urakawa, A., Cho, Y., Kataoka, Y., Watanabe, Y.
    • Journal Title

      International Journal of Neuroscience 118(10)

      Pages: 1400-1411

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The neural basis of academic achievement motivation.2008

    • Author(s)
      Mizuno, K., Tanaka, M., Ishii, A., Tanabe, C. H., Onoe, H., Sadato, N., Watanabe, Y.
    • Journal Title

      NeuroImage 42(1)

      Pages: 369-378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The neural basis of academic achievement motivation2008

    • Author(s)
      Mizuno Kei
    • Journal Title

      Neurolmage 42

      Pages: 369-378

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan2008

    • Author(s)
      Tanaka Masaaki
    • Journal Title

      Psychological Reports 103

      Pages: 683-690

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors influencing the academic motivation of individual college students2008

    • Author(s)
      Yoshida Masahiro
    • Journal Title

      International Journal of Neuroscience 118

      Pages: 1400-1411

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Interdisciplinary research of neuroscience and education for elucidating the neural mechanisms of fatigue and motivation to learn in children and adolescents.2010

    • Author(s)
      Mizuno, K., Tanaka, M., Miike, T., Imai-Matsumura, K., Sadato, N. Watanabe, Y
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience "Casting light on life"
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-12-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Interdisciplinary research of neuroscience and education for elucidating the neural mechanisms of fatigue and motivation to learn in children and adolescents.2010

    • Author(s)
      Mizuno Kei
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience "Casting light on life"
    • Place of Presentation
      Sheraton Miyako Hotel (Tokyo)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Excessive neural activation during divided attention processing in childhood chronic fatigue syndrome.2010

    • Author(s)
      Mizuno Kei
    • Organizer
      American Academy of Children & Adolescent Psychiatry (AACAP) 57th Annual Meeting
    • Place of Presentation
      Hilton New York (New York, U.S.A.)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neurological relationship between divided attention and motivation : an fMRI study.2010

    • Author(s)
      Mizuno, K., Tanabe, C.H., Tanaka, M., Sadato, N. Watanabe, Y
    • Organizer
      The 33th Annual Meeting of the Japan Neuroscience Society (Neuro 2010)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児慢性疲労症候群におけるATMTを用いた認知機能のコホート調査2010

    • Author(s)
      川谷淳子、水野敬
    • Organizer
      第6回日本疲労学会総会・学術集会
    • Place of Presentation
      大阪産業創造館(大阪)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小中学生における疲労関連症状の持続及び出現の危険因子2010

    • Author(s)
      山野恵美、水野敬
    • Organizer
      第6回日本疲労学会総会・学術集会
    • Place of Presentation
      大阪産業創造館(大阪)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児慢性疲労症候群患児と健常児に共通する疲労と神経過剰賦活の関係2010

    • Author(s)
      水野敬
    • Organizer
      第6回日本疲労学会総会・学術集会
    • Place of Presentation
      大阪産業創造館(大阪)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児型慢性疲労症候群におけるコホート研究-Advanced Trail Making Testを用いた検討-2010

    • Author(s)
      川谷淳子、水野敬
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 機能的MRIを用いた思春期の慢性疲労による注意配分機能低下の神経基盤に関する検討2010

    • Author(s)
      水野敬
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigation of neural substrates associated with fatigue and motivation using functional neuroimaging.2010

    • Author(s)
      Mizuno, K.
    • Organizer
      The Thirteenth Conference of Peace through Mind/Brain Science
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2010-02-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Investigation of neural substrates associated with fatigue and motivation using functional neuroimaging.2010

    • Author(s)
      Mizuno Kei
    • Organizer
      The Thirteenth Conference of Peace through Mind/Brain Science
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Attentional functions in childhood chronic fatigue syndrome.2009

    • Author(s)
      Mizuno Kei
    • Organizer
      American Academy of Children & Adolescent Psychiatry (AACAP) 56th Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] ADHD and chronic fatigue in childhood.2009

    • Author(s)
      Tomoda Akemi, Mizuno Kei
    • Organizer
      American Academy of Children & Adolescent Psychiatry (AACAP) 56th Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lifestyle habit and sleep disturbance among school children in Japan : The 2-year follow-up study.2009

    • Author(s)
      Yamano Emi, Mizuno Kei
    • Organizer
      The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural substrates associated with divided attention in childhood chronic fatigue syndrome.2009

    • Author(s)
      Mizuno Kei
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 疲労関連症状出現と心理社会的予測因子の検討-追跡調査の結果から-2009

    • Author(s)
      山野恵美、水野敬
    • Organizer
      第5回日本疲労学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 疲労と光過敏性の関係2009

    • Author(s)
      鴫原良仁、水野敬
    • Organizer
      第5回日本疲労学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児・思春期の疲労による高次脳機能低下2009

    • Author(s)
      水野敬
    • Organizer
      第5回日本疲労学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳磁図を用いて明らかになった疲労の脳神経学的メカニズム2009

    • Author(s)
      田中雅彰、水野敬
    • Organizer
      第5回日本疲労学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Selective and divided attention in childhood chronic fatigue syndrome2009

    • Author(s)
      Mizuno Kei
    • Organizer
      9th International IACFS/ME Conference
    • Place of Presentation
      Reno, Nevada, USA
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural substrates of motivation to learn and fatigue sensation.2008

    • Author(s)
      Mizuno, K., Tanaka, M., Tajima, S., Tanabe, C.H., Kataoka, Y., Onoe, H., Sadato, N., Watanabe, Y.
    • Organizer
      The 2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice, France
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Neural substrates of motivation to learn and fatigue sensation2008

    • Author(s)
      Mizuno Kei
    • Organizer
      The 2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice, France
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural substrates of academic achievement motivation related to neural mechanism of fatigue.2008

    • Author(s)
      Mizuno, K., Tanaka, M., Tanabe, C.H., Onoe, H., Sadato, N., Watanabe, Y.
    • Organizer
      International Conference on Fatigue Science 2008
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2008-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Neural substrates of academic achievement motivation related to neural m echanism of fatigue2008

    • Author(s)
      Mizuno Kei
    • Organizer
      International Conference on Fatigue Science
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Book] 最新・疲労の科学 -日本初:抗疲労・抗過労への提言(疲労による作業能率低下の解析.医学のあゆみ)228(6)2009

    • Author(s)
      水野敬
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 疲労による作業能率低下の解析。医学のあゆみ(最新・疲労の科学-日本初 : 抗疲労・抗過労への提言)2009

    • Author(s)
      水野敬
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] 現代化学「特集 疲労の科学」(疲れはどこで感じるのか?-脳機能イメージングを用いた疲れの脳科学-)2008

    • Author(s)
      水野敬, 渡辺恭良
    • Publisher
      東京化学同人社
    • Related Report
      2010 Final Research Report
  • [Book] 精神医学[疲労と精神障害(ストレス-疲労-精神障害について)](疲労の脳内機序(Brain Dysfunction in Fatigue and Chronic Fatigue))50(6)2008

    • Author(s)
      渡辺恭良, 田中雅彰, 水野敬
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] Utility of an advanced trail making test as a neuropsychological tool for an objective evaluation of work efficiency during mental fatigue.(Fatigue Science for Human Health)(Watanabe, Y., Evengard, B., Natelson, B. H., Jason, L. A., Kuratsune, H.)2008

    • Author(s)
      Mizuno, K., Watanabe, Y.
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Utility of an advanced trail making test as a neuropsychological tool for an objective evaluation of work efficiency during mental fatigue. In: Fatigue Science for Human Health2008

    • Author(s)
      Mizuno Kei
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Book] 疲労の脳内機序(Brain Dysfuction in Fatigue and Chronic Fatigue).精神医学[疲労と精神障害(ストレスー疲労-精神障害について)2008

    • Author(s)
      渡辺恭良
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Book] 疲れはどこで感じるのか?-脳機能イメージングを用いた疲れの脳科学-現代化学(特集疲労の科学」2008

    • Author(s)
      水野敬
    • Publisher
      東京化学同人社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体疲労評価装置2009

    • Inventor(s)
      金井江都子、水野敬
    • Industrial Property Rights Holder
      金井江都子、水野敬
    • Industrial Property Number
      2009-249537
    • Filing Date
      2009-10-29
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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