Elucidation of the Mechanism of non-alcoholic steatohepatitis induced by oxidative stress

• Project/Area Number: 20700550
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: NAKAMOTO Kazuo Okayama University, 薬学部, 講師 (30432636)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 非アルコール性脂肪性肝炎 / 酸化ストレス / 抗酸化物質 / 予防医学 / NASH / 低酸素 / ミトコンドリア

Research Abstract

Our present study demonstrated that mitochondrial abnormality might contribute to the progression of NASH in correlation with oxidative stress. Furthermore, Fermented green tea extracts administration prevent the mitochondrial damage and may be beneficial in preventing NASH development.

Research Products

• [Journal Article] A Novel Animal Model of Nonalcoholic Steatohepatitis (NASH): Hypoxemia Enhances the Development of NASH. (2009)
  • Author(s): Takayama Fusako, Egashira Toru, Kawasaki Hiromu, Mankura Mitsumasa, Nakamoto Kazuo, Okada Shigeru, Mori Akitane
  • Journal Title: J Clin Biochem Nutr 45 Pages: 335-340
  • NAID: 130004879182
  • Peer Reviewed
• [Journal Article] Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. (2009)
  • Author(s): Takayama Fusako, Nakamoto Kazuo, Hasegawa Azusa, Mankura Mitsumasa, Egashira Toru, Ueki Keiji, Kawasaki Hiromu, Okada Shigeru, Mori Akitane
  • Journal Title: Acta Med Okayama 63 Pages: 105-111
  • NAID: 120002313148
  • Peer Reviewed
• [Journal Article] Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis. (2009)
  • Author(s): Nakamoto Kazuo, Takayama Fusako, Mankura Mitsumasa, Hidaka Yuki, Egashira Toru, Ogino Tetsuya, Kawasaki Hiromu, Mori Akitane
  • Journal Title: J Clin Biochem Nutr 44 Pages: 239-246
  • NAID: 130004466546
  • Peer Reviewed
• [Journal Article] Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steato hepatitis (2009)
  • Author(s): Nakamoto K, Takayama F, Mankura M, Hidaka Y, Egashira T, Ogino T, Kawasaki H, Mori A
  • Journal Title: Journal of Clinical Biochemistry and Nutrition 44 Pages: 239-246
  • Peer Reviewed
• [Journal Article] A Novel Animal Model of Nonalcoholic Steatohepatitis (NASH): Hypoxemia Enhances the Development of NASH (2009)
  • Author(s): Takayama F, Egashira T, Kawasaki H, Mankura M, Nakamoto K, Okada S, Mori A
  • Journal Title: Journal of Clinical Biochemistry and Nutrition 45 Pages: 335-340
  • NAID: 130004879182
  • Peer Reviewed
• [Presentation] 緑茶発酵物エキスの生体内レドックス制御機能と非アルコール性脂肪性肝炎への有効性に関する研究 (2008)
  • Author(s): 中本賀寿夫、高山房子、万倉三正、川崎博已、森昭胤
  • Organizer: 第10回創薬薬理フォーラム岡山
  • Place of Presentation: 岡山市
  • Year and Date: 2008-12-21
• [Presentation] 緑茶発酵物エキスの生体内レドックス制御機能と非アルコール性脂肪性肝炎への有効 (2008)
  • Author(s): 中本賀寿夫
  • Organizer: 第10回創薬薬理フォーラム岡山
  • Place of Presentation: 岡山市
  • Year and Date: 2008-12-21
• [Presentation] 緑茶発酵物水抽出エキスの非アルコール性脂肪性肝炎モデルラットに対する予防効果について (2008)
  • Author(s): 中本賀寿夫、高山房子、万倉三正、川崎博己、森昭胤
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都市
• [Presentation] Preventive effect of FGTE against an experimental NASH model rats. (2008)
  • Author(s): Kazuo Nakamoto, Fusako Takayama, Mitsumasa Mankura, Toru Egashira, Tetsuya Ogino, Utsumi Kozo, Akitane Mori
  • Organizer: SFRBM's 15th Annual Meeting
  • Place of Presentation: Indianapolis, USA
• [Presentation] 緑茶発酵物水抽出エキスの非アルコール性脂肪性肝炎モデルラットに対する予防効果 (2008)
  • Author(s): 中本賀寿夫
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都市
• [Presentation] Preventive effect of FGTE against an experimental NASH model rats (2008)
  • Author(s): Kazuo Nakamoto
  • Organizer: SFRBM's 15th Annual Meeting
  • Place of Presentation: Indianapolis, USA