• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Improvement of insulin resistance by exercise in chronic hepatitis C patients

Research Project

Project/Area Number 20700552
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionEhime University

Principal Investigator

KONISHI Ichiro  Ehime University, 医学系研究科, 講師 (30403801)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsC型肝炎ウイルス / 運動療法 / インスリン抵抗性 / 酸化ストレス / 内臓脂肪 / 糖尿病 / 慢性肝炎 / 肝硬変
Research Abstract

We conducted a study to clarify whether walking combined with diet therapy improves insulin resistance and obesity in chronic hepatitis C (CH-C) patients. While body weight, body mass index and HOMA-IR decreased significantly during this study. On the other hand, liver functions did not get worse. In vitro, Hepatitis C virus (HCV) inhibited the uptake of glucose in the HCV infected cells. Aerobic exercise such as walking is useful to improve obesity and insulin resistance, and can be performed safely in CH-C patients.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] Diabetes pattern on the 75 g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus.2009

    • Author(s)
      Konishi I, Hiasa Y, Shigematsu S, Hirooka M, Furukawa S, Abe M, Matsuura B, Michitaka K, Horiike N, Onji M
    • Journal Title

      Liver International 29

      Pages: 1194-1201

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes pattern on the 75g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus2009

    • Author(s)
      Konishi I, Hiasa Y, Shigematsu S, Hirooka M, Furukawa S, Abe M, Matsuura B, Michitaka K, Horiike N, Onji M
    • Journal Title

      Liver International 29

      Pages: 1194-1201

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) through enhancing interferon-beta.2008

    • Author(s)
      Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Onji M, et al.
    • Journal Title

      Hepatology 48

      Pages: 59-69

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis.2008

    • Author(s)
      Michitaka K, Tokumoto Y, Konishi I, Onji M, et al.
    • Journal Title

      Hepatology Research 38

      Pages: 1069-1075

    • NAID

      10024304981

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] c型肝炎とQOL2008

    • Author(s)
      小西一郎, 日浅陽一, 恩地森一
    • Journal Title

      肝胆膵 57巻

      Pages: 1169-1178

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] C型肝炎とQOL2008

    • Author(s)
      小西一郎、日浅陽一、恩地森一
    • Journal Title

      肝胆膵 57

      Pages: 1169-1178

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12- ene-3beta, 24(4beta)-diol (ME3738) through enhancing interferon-beta2008

    • Author(s)
      Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Onji M, et.al.
    • Journal Title

      Hepatology 48

      Pages: 59-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychiatric dysfunction in patients with chronic hepatitis an liver cirrhosis2008

    • Author(s)
      Michitaka K, Tokumoto Y, Konishi I, Onji M, et.al.
    • Journal Title

      Hepatol Res 38

      Pages: 1069-1075

    • NAID

      10024304981

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血小板減少を伴ったC型肝炎に対する抗ウイルス療法の効果-脾摘・PSE施行例-2009

    • Author(s)
      小西一郎, 日浅陽一, 阿部雅則, 広岡昌史, 恩地森一
    • Organizer
      第13回日本肝臓学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 血小板減少を伴ったC型肝炎に対する抗ウイルス療法の効果-脾摘・PSE施行例-2009

    • Author(s)
      小西一郎、日浅陽一、阿部雅則、広岡昌史、恩地森一
    • Organizer
      第13回 日本肝臓学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型慢性肝炎における耐糖能異常が肝発癌に及ぼす影響について2008

    • Author(s)
      小西一郎, 日浅陽一, 世良俊樹, 重松秀一郎, 道堯浩二郎, 堀池典生, 恩地森一
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山
    • Year and Date
      2008-06-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 小西一郎、日浅陽一、世良俊樹、重松秀一郎、道尭浩二郎、堀池典生、恩地森一2008

    • Author(s)
      小西一郎、日浅陽一、世良俊樹、重松秀一郎、道尭浩二郎、堀池典生、恩地森一
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi