Elucidation of new molecular basis for prevention of obesity through the systems of nutritional sensor

• Project/Area Number: 20700555
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: University of Shizuoka
• Principal Investigator: ARAI Hidekazu University of Shizuoka, 食品栄養科学部, 准教授 (60325256)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 生活習慣病 / キシリトール / 高脂肪食 / 内臓脂肪蓄積 / 褐色脂肪 / 熱産生

Research Abstract

Here we investigated the effects of dietary xylitol on lipid metabolism and visceral fat accumulation in rats fed a high-fat diet. Visceral fat mass and plasma lipid concentrations were significantly lower in xylitol-fed rats than those in HFD rats. Gene expression levels of PPARγ, adiponectin and lipolysis enzymes in the adipose tissue of rats in the xylitol group were significantly higher. Furthermore, the expression levels of fatty acid oxidation-related genes in the liver of xylitol-fed rats were significantly higher than those of HFD rats. In conclusion, intake of xylitol may be beneficial in preventing the development of obesity and metabolic abnormalities. However, the mechanism of prevention for the fat accumulation by the xylitol intake is unknown.

Research Products

• [Journal Article] Hypocaloric high protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways. (2009)
  • Author(s): Uebanso T
  • Journal Title: Am J Physiol Endocrinol Metab. 297(1) Pages: 76-84
  • Peer Reviewed
• [Journal Article] Immprovement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as apart of breakfast. (2009)
  • Author(s): Sakuma M
  • Journal Title: J Clin Biochem Untr. 45(2) Pages: 155-162
  • Peer Reviewed
• [Journal Article] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats (2008)
  • Author(s): Sato K
  • Journal Title: J Med Invest 55(3-4) Pages: 183-195
  • Peer Reviewed
• [Presentation] 健常者の代謝変化を反映する指標および要因の検討 (2010)
  • Author(s): 佐久間理英
  • Organizer: 日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 2010-01-10
• [Presentation] 健常者の代謝変化を反映する指標および要因の検討 (2010)
  • Author(s): 佐久間理英、勝田沙耶香、小林加奈、松田千晶、松浦基、新井英一
  • Organizer: 日本病態栄養学会第13回学術集会
  • Place of Presentation: 京都
• [Presentation] Effects of Long-term Intake of Xylitol on Visceral Fat Accumulation in Rats Fed High Fat Diet (2008)
  • Author(s): Arai H
  • Organizer: 15th International Congress of Dietetics
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2008-09-09
• [Presentation] Effects of Long-term Intake of Xylitol on Visceral Fat Accumulation in Rats Fed High Fat Diet. (2008)
  • Author(s): Arai H., Amo K., Uebanso T., Fukaya M., Yamamoto M., Koganei M., Sasaki H., Yamamoto H., Taketani Y., Takeda E.
  • Organizer: 15th International Congress of Dietetics
  • Place of Presentation: 横浜