The role of PKCδ on signal transduction of muscle atrophy
| Project/Area Number |
20700559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
TAMURA Yoshifumi Juntendo University, 医学部, 准教授 (80420834)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 筋萎縮 / インスリン抵抗性 / 廃用性筋萎縮 / PKCδ / 酸化ストレス / PKC δ |
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| Research Abstract |
(Aim) To clarify the role of PKC-delta on disuse muscle atrophy. (Method) We investigated muscle atrophy and signal transduction of hind-limb model in PKC-delta KO mice. (Result) In PKC-delta KO mice, weight of soleus muscle was lower than those in control mice. Muscle atrophy induced by hind-limb was similar between the groups. (Conclusion) Our result suggested that PKC-delta may contribute to the size of soleus muscle, while it may not affect on disuse muscle atrophy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.2010
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
J Diabetes Invest in press
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[Journal Article] Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners.2008
Author(s)
Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R
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Journal Title
Metabolism 57
Pages: 373-379
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[Journal Article] Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.2008
Author(s)
Tamaki M, Shimizu T, Kanazawa A, Tamura Y, Hanzawa A, Ebato C, Itou C, Yasunari E, Sanke H, Abe H, Kawai J, Okayama K, Matsumoto K, Komiya K, Kawaguchi M, Inagaki N, Watanabe T, Kanazawa Y, Hirose T, Kawamori R, Watada H
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Journal Title
Diabetes Res Clin Pract 81
Pages: 296-302
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