Effect of zinc and polyunsaturated fatty acid on chronic hepatitis C.

• Project/Area Number: 20700596
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Fukuyama University (2009-2011); Okayama Prefectural University (2008)
• Principal Investigator: MURAKAMI Yasuko 福山大学, 生命工学部, 講師 (90326413)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 慢性肝炎 / 亜鉛 / エイコサペンタエン酸 / 肝線維化 / EPA / 慢性肝疾患 / 魚油

Research Abstract

We investigated the effects of zinc and eicosapentaenoic acid(EPA) supplementation on the liver injury, fibrosis and antioxidant capacity in animal chronic liver disease model. EPA supplementation improved serum transaminase levels and hepatic oleic acid accumulation. These findings may indicate that EPA supplementation improves liver inflammation and hepatic lipid metabolism in chronic liver disease patients.

Research Products

• [Journal Article] 非アルコール性脂肪性肝炎(NASH)患者における食事療法と抗酸化ビタミンおよびEPA投与の影響 (2010)
  • Author(s): 川上貴代、村上泰子、冨岡加代子、沖田美佐子
  • Journal Title: 日本臨床栄養学雑誌 Volume: 31-1 Pages: 32-38
  • NAID: 10029421046
  • Peer Reviewed
• [Journal Article] 非アルコール性脂肪性肝炎(NASH)患者における食事療法と抗酸化ビタミンおよびEPA投与の影響 (2010)
  • Author(s): 川上貴代, 村上泰子, 冨岡加代子, 沖田美佐子
  • Journal Title: 臨床栄養学雑誌 31(1) Pages: 32-38
  • NAID: 10029421046
  • Peer Reviewed
• [Journal Article] 非アルコール性脂肪性肝炎(NASH)患者における食事療法と抗酸化ビタミンおよびEPA投与の影響 (2010)
  • Author(s): 川上貴代、村上泰子、冨岡加代子、沖田美佐子
  • Journal Title: 臨床栄養学雑誌 Volume: 31(1) Pages: 32-38
  • NAID: 10029421046
  • Peer Reviewed
• [Presentation] Supplementation of antioxidative vitamins treatment for nonalcoholic steatohepatitis (2011)
  • Author(s): T. Kawakami, Y. Murakami, K. Tomioka, M. Tabuchi, K. Katayama, M. Okita
  • Organizer: 7th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2011-06-07
• [Presentation] Supplementation of antioxidative vitamins treatment for nonalcoholic steatohepatitis (2011)
  • Author(s): T Kawakami, Y.Murakami, K.Tomioka, M.Tabuchi, K.Katayama, M.Okita
  • Organizer: 7th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Sofitel Centara Grand Bangkok (Bangkok, Thailand)
  • Year and Date: 2011-06-07
• [Presentation] 株化肝星細胞活性化に及ぼす亜鉛動態の影響 (2011)
  • Author(s): 川上貴代、片山敬子、村上泰子、冨岡加代子、田淵真愉美
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] 株化肝星細胞活性化に及ぼす亜鉛動態の影響 (2011)
  • Author(s): 川上貴代、片山敬子、村上泰子、冨岡加代子、田淵真愉美
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水大学(東京都)
  • Year and Date: 2011-05-14
• [Presentation] 肝線維化モデルラットにおける亜鉛投与の影響 (2009)
  • Author(s): 片山敬子、村上泰子, 他
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2009-05-21
• [Presentation] 肝線維化モデルラットにおける亜鉛投与の影響 (2009)
  • Author(s): 片山敬子
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: ブリックホール(長崎市)
  • Year and Date: 2009-05-21