| Project/Area Number |
20700597
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fuji Women's University |
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Principal Investigator |
OKAZAKI Yukako Fuji Women's University, 人間生活学部, 講師 (80433415)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | セリシン / メタボリックシンドローム / アディポサイトカイン / 腸内環境 / 栄養学 / ラット / 高脂肪食 / 盲腸有機酸 / 腸内細菌叢 / 肝障害 / 血清AST / 血清ALT / アディポネクチン / 脂質代謝 / 糖代謝 / IgA / 脂肪酸合成関連酵素 / 肝臓脂肪 / 高脂血症 |
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| Research Abstract |
This study was performed to examine the effect of dietary sericin on the lipid and carbohydrate metabolisms in rats fed high-fat diet. Consumption of sericin significantly reduced serum and liver lipids and the activities of the lipogenic enzymes. Dietary sericin suppressed the increases in plasma glucose and insulin levels after intraperitoneal glucose injection. Dietary sericin caused a marked elevation in serum adiponectin. These results imply that the increase in serum adiponectin by sericin intake may, at least in part, contribute to the protective effect against hyperlipidemia, fatty liver and glucose intolerance in rats fed a high-fat diet. Consumption of sericin markedly elevated fecal immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function) and cecal organic aicds in rats fed the high-fat diet. There was an inverse correlation between serum triglyceride and cecal acetate. These results imply that sericin is a useful agent for improving lipid and carbohydrate metabolisms and intestinal luminal environments in rats fed a high-fat diet.
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