Inhibitory effects of methoxyflavonoid on hormone-dependent cancer related to environmental factor

• Project/Area Number: 20700601
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Matsumoto University
• Principal Investigator: TAKEMURA Hitomi Matsumoto University, 人間健康学部, 助手 (60295558)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ホルモン依存性癌 / メトキシフラボノイド / Benzo[a]pyrene / CYP / DNA付加体 / アリル炭化水素受容体 / エストロゲン代謝 / がん化学予防 / cytochrome P450 / benzo[a]pyrene / フラボノイド / benzo[a]prene

Research Abstract

A dietary methoxyflavonoid, chrysoeriol, inhibited the formation of BPDE-DNA adducts in human MCF-7 breast cancer cells, via regulation of the AhR pathway stimulated by benzo[a]pyrene, which is a ubiquitous environmental pollutant.

Research Products

• [Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. (2010)
  • Author(s): Takemura H, Uchiyama H, Ohura T, Sakakibara H, Kuruto R, Amagai T, Shimoi K.
  • Journal Title: J. Steroid Biochem. Mol. Biol. 118 Pages: 70-76
  • Peer Reviewed
• [Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells (2010)
  • Author(s): Takemura H, Uchiyama H, Ohura T, Sakakibara H, Kuruto R, Amagai T, Shimoi K
  • Journal Title: J.Steroid Biochem.Mol.Biol. 118 Pages: 70-76
  • Peer Reviewed
• [Journal Article] Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
  • Author(s): Takemura H, Nagayoshi H, Matsuda T, Sakakibara H, Morita M, Matsui A, Ohura T, Shimoi K.
  • Journal Title: Toxicology (in press)
  • Peer Reviewed
• [Presentation] CYPによるエストラジオールの位置選択的水酸化機構解明に関する研究 (2010)
  • Author(s): 伊藤俊将、竹村ひとみ、下位香代子、山本恵子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 桃太郎アリーナ(岡山県)
  • Year and Date: 2010-03-29
• [Presentation] Inhibitory selectivity of flavonoids on human CYP1A1, 1A2 and 1B1 enzymes: molecular modeling and docking study. (2009)
  • Author(s): Takemura H.
  • Organizer: 4th International Conference on Polyphenols and Health.
  • Place of Presentation: Harrogate International Centre (Harrogate, UK)
  • Year and Date: 2009-12-08
• [Presentation] Inhibitory selectivity of flavonoids on human CYP1A1, 1A2 and 1B1 enzymes : molecular modeling and docking study (2009)
  • Author(s): 竹村ひとみ、伊藤俊将、山本恵子、榊原啓之、下位香代子
  • Organizer: 4^<th> International Conference on Polyphenols and Health
  • Place of Presentation: Harrogate International Centre(Harrogate, UK)
  • Year and Date: 2009-12-08
• [Presentation] ヒトCYP1酵素活性に対するフラボノイドの選択的阻害～モデリング・ドッキング解析による検証～ (2009)
  • Author(s): 竹村ひとみ
  • Organizer: 第14回日本フードファクター学会学術集会
  • Place of Presentation: 神戸大学百年記念館(兵庫県)
  • Year and Date: 2009-11-16
• [Presentation] Benzo[a]pyrene-DNA付加体形成に対するchrysoeriolの抑制効果 (2008)
  • Author(s): 竹村ひとみ
  • Organizer: 日本環境変異原学会37回大会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)
  • Year and Date: 2008-12-04
• [Presentation] Benzo[a]pyrene-DNA付加体形成に対するchrysoeriolの抑制効果 (2008)
  • Author(s): 竹村ひとみ
  • Organizer: 日本環境変異原学会37回大会
  • Place of Presentation: 沖縄県宜野湾市
  • Year and Date: 2008-12-04