Elucidation of lipid metabolic disorder and liver injury on the high fat diet

Research Project

Project/Area Number	20700603
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	Kinjo Gakuin University
Principal Investigator	KITAMORI Kazuya Kinjo Gakuin University, 生活環境学部, 講師 (80387597)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	NAFLD / NASH / 高脂肪食 / 炎症 / モデル動物
Research Abstract	Patients with nonalcoholic fatty liver disease (NAFLD) are increasing worldwide, and preventive measures are an urgent need and primary concern today. The purpose of this study is to develop and clarify the usefulness of the SHRSP5/Dmcr rat as an animal model for human NAFLD. We have developed animal model of the NAFLD progression as observed in humans using SHRSP5/Dmcr rats fed an HFC diet. This model appears to be useful to investigate the mechanism of human NAFLD progression.

Report

(3 results)