| Project/Area Number |
20700606
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Otani Womens University |
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Principal Investigator |
UEDA Hidenori Otani Womens University, 薬学部, 助教 (50419462)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 必須金属 / 妊娠 / 胎盤 / 胎児 / 栄養状態 / 必須微量元素 |
|---|
| Research Abstract |
Effects of maternal deficiency or supplementation of essential metals on fetal development were studied in human placental choriocarcinoma cell line JEG-3, human ovarian granulosa cell line KGN, and mice. The synthesis of female sex hormones was up-regulated by zinc deficiency, but down-regulated by zinc supplement in both cells. Iron deficiency resulted in up-regulation of iron transport system in placenta as in small intestine and loss of fetus weight in mice. These results suggest that placenta is most important tissue for regulation of fetus nutrition for essential metals and maternal nutrition for zinc and iron is important for fetus development.
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