Effect of funotional food factor in citrus fruits on catecholamine secretion in cultured bovine adrenal medurally cells.

• Project/Area Number: 20700611
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Seinan Jo Gakuin University
• Principal Investigator: SAKAMAKI Ruka Seinan Jo Gakuin University, 保健福祉学部, 准教授 (80389486)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 神経系 / カテコールアミン / アセチルコリン / 副腎髄質細胞 / フラボノイド / オーラプテン

Research Abstract

In the present study we report the effects of citrus fruit-derived functional food factor on catecholamine secretion in cultured bovine adrenal medullary cells. Auraptene and nomilin decreased catecholamine secretion elicited by acetylcholine and veratridine. Nomi lin modestly inhibited catecholamine secretion elicited by high K. These findings suggest that citrus flavonoids modulate the functions of the adrenal medulla and probably noradrenergic neurons.

Research Products

• [Journal Article] Effect of nomilin, citrus limonoid, on catecholamine secretion and noradrenaline uptake in cultured bovine adrenal madullary cells. (2010)
  • Author(s): umiko Toyohira, Ruka Sakamaki, Kojiro Takahashi, Susumu Ueno, Kenji Toyama, Nobuyuki Yanagihara
  • Journal Title: Journal of Pharmacological sciences VOL.112 Pages: 193-193
  • Peer Reviewed
• [Journal Article] Effect of nomilin, citrus limonoid, on catecholamine secretion and noradrenaline uptake in cultured bovine adrenal madullary cells (2010)
  • Author(s): Ruka Sakamaki
  • Journal Title: Journal of Pharmacological Sciences VOL.112 Pages: 193-193
  • Peer Reviewed
• [Journal Article] Effects of citrus flavonoids on catecholamine secretion in cultured bovine adrenal medullary cells (2009)
  • Author(s): Ruka Sakamaki
  • Journal Title: Journal of Pharmacological Sciences 109, Suppl Pages: 264-264
  • Peer Reviewed
• [Presentation] Effect of nomilin, citrus limonoid, on cateeholamine Secretion and noradreBaline uptake in cultured bovine adrenal maduUary cells (2010)
  • Author(s): 豊平由美子、坂巻路可、高橋浩二郎、上野晋、外由健二、柳原延章
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-17
• [Presentation] Effect of nomilin, citrus limonoid, on catecholamine secretion and noradrenaline uptake in cultured bovine adrenal madullary cells (2010)
  • Author(s): 豊平由美子
  • Organizer: 第83回 日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-17
• [Presentation] 柑橘系フラボノイドのカテコールアミン神経系に及ぼす影響-培養ウシ副腎髄質細胞での検討- (2009)
  • Author(s): 坂巻路可、豊平由美子、上野晋、高橋浩二郎、外由健二、柳原延章
  • Organizer: 第27回産業医科大学学会総会
  • Place of Presentation: 産業医科大学(福岡)
  • Year and Date: 2009-10-06
• [Presentation] 柑橘系フラボノイドのカテコールアミン神経系に及ぼす影響―培養ウシ副腎髄質細胞での検討― (2009)
  • Author(s): 坂巻路可
  • Organizer: 第27回 産業医科大学学会総会
  • Place of Presentation: 産業医科大学(福岡)
  • Year and Date: 2009-10-06
• [Presentation] 副腎髄質細胞におけるカテコールアミン分泌に及ぼす柑橘系フラボノイドの影響 (2009)
  • Author(s): 坂巻路可
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-18