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Identification and quantification of food-derived peptide in human blood after oral ingestion of collagen peptides

Research Project

Project/Area Number 20700613
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionOsaka Joshigakuen Junior College

Principal Investigator

SHIGEMURA Yasutaka  Osaka Joshigakuen Junior College, 食物学科, 助手 (20373178)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsコラーゲン / ペプチド / ハイドロキシプロリン / 皮膚 / 線維芽細胞 / Pro-Hyp / Hyp-Gly / ヒドロキシプロリン / プロリン / 食事由来ペプチド
Research Abstract

In present study, We quantified the concentration of food-derived peptides and identified the amino acid sequence of the peptides after oral ingestion of collagen peptides. The concentration of food-derived peptides in human blood dependently increased by the concentration of ingested collagen peptides. The food-derived Pro-Hyp decreased and food-derived Hyp-Gly increased in human blood by the long-term ingestion of collagen peptides.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (22 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] コラーゲンペプチド経口摂取による生理機能とそのメカニズム2010

    • Author(s)
      重村泰毅、佐藤健司
    • Journal Title

      食品加工技術 30巻(1)

      Pages: 40550-40550

    • Related Report
      2009 Final Research Report
  • [Journal Article] コラーゲンペプチド経口摂取による生理機能とそのメカニズム2010

    • Author(s)
      重村泰毅
    • Journal Title

      食品加工技術 30

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of Prolyl-Hydroxyproline (Pro-Hyp)、a Food-Derived Collagen Peptide in Human Blood、on Growth of Fibroblasts from Mouse Skin2009

    • Author(s)
      Yasutaka Shigemura、Koji Iwai、Fumiki Morimatsu、Taka-aki Iwamoto、Toshio Mori、Chikako Oda、Toshio Taira、Eun Young Park、Yasusi Nakamura、Kenji Sato
    • Journal Title

      Journal of Agriculture and Food Ch emistry 57(2)

      Pages: 444-449

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Prolyl-Hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin2009

    • Author(s)
      Yasutaka Shigemura, Koji Iwai, Fumiki Morimatsu, Takaaki Iwamoto, Toshio Mori, Chikako Oda, Toshio Taira, Eun Young Park, Yasusi Nakamura, Kenji Sato
    • Journal Title

      Journal of Agriculture and Food Chemistry 57(2)

      Pages: 444-449

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲンペプチドの経口摂取とその生理機能2008

    • Author(s)
      佐藤健司・岩井浩二・井上美佐子・重村泰毅・森俊雄・平敏夫
    • Journal Title

      グルコサミン研究会 4巻

      Pages: 57-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] コラーゲンペプチドの経口摂取とその生理機能2008

    • Author(s)
      佐藤健司・岩井浩二・井上美佐子・重村泰毅・森俊雄・平敏夫
    • Journal Title

      グルコサミン研究会 4

      Pages: 57-62

    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp) on proliferation of skin fibroblasts: A possible mechanism for improvement of skin condition by collagen peptide ingestion2010

    • Author(s)
      Yasutaka Shigemura
    • Organizer
      The 5th Joint Graduate School Seminar Kyoto、The 5th Joint Graduate School Seminar Kyoto
    • Place of Presentation
      Kyoto Prefecture Univ.
    • Year and Date
      2010-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline(Pro-Hyp)on proliferation of skin fibroblasts : A possible mechanism for improvement of skin condition by collagen peptide ingestion2010

    • Author(s)
      重村泰毅
    • Organizer
      The 5th Joint Graduate School Seminar Kyoto
    • Place of Presentation
      Kyoto Prefecture Univ.
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] プレカラム誘導法に基づくヒト血液中からの食事由来ペプチド検出方法2010

    • Author(s)
      重村泰毅
    • Organizer
      バイオ計測・試薬分野における若手科学者・技術者のシーズ・構想発表会
    • Place of Presentation
      京都高度技術研究所
    • Year and Date
      2010-03-01
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 食事由来エラスチンペプチド、Pro-Glyの検出と同定2009

    • Author(s)
      重村泰毅
    • Organizer
      第3回京都3大学連携研究発表会
    • Place of Presentation
      京都府立医科大学
    • Year and Date
      2009-12-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事由来エラスチンペプチド、Pro-Gly の検出と同定2009

    • Author(s)
      重村泰毅
    • Organizer
      3大学連携
    • Place of Presentation
      京都府立医科大学
    • Year and Date
      2009-12-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a food-derived elastin peptide (Pro-Gly) in human blood after oral ingestion of elastin hydrolysate2009

    • Author(s)
      Yasutaka Shigemura、Misako Nakaba、Eun Young Park、Yasushi Nakamura、Kenji Sato
    • Organizer
      ISNFF (The International Society for Nutraceuticals and Functional Foods) 2009
    • Place of Presentation
      San Francisco、CA、USA
    • Year and Date
      2009-11-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of a food-derived elastin peptide(Pro-Gly)in human blood after oral ingestion of elastin hydrolysate2009

    • Author(s)
      重村泰毅
    • Organizer
      ISNFF
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食事由来コラーゲンペプチド、(Pro-Hyp、Hyp-Gly)の吸収と血液中での分解2009

    • Author(s)
      重村泰毅
    • Organizer
      第7回高付加価値食品開発のためのフォーラム
    • Place of Presentation
      富士教育研究所
    • Year and Date
      2009-09-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事由来コラーゲンペプチド、(Pro-Hyp, Hyp-Gly)の吸収と血液中での分解2009

    • Author(s)
      重村泰毅
    • Organizer
      第7回高付加価値食品開発のためのフォーラム
    • Place of Presentation
      富士教育研究所
    • Year and Date
      2009-09-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト抹消血における食事由来エラスチンペプチドの検出2009

    • Author(s)
      重村泰毅、中場操子、朴恩榮、中村考志、佐藤健司
    • Organizer
      第63回栄養食糧学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp) on proliferation of skin fibroblasts: A possible mechanism for improvement of skin condition by collagen peptide ingestion2009

    • Author(s)
      Yasutaka Shigemura、Kenji Sato
    • Organizer
      ACS (American Chemical Society) 2009 National Meeting & Exposition Division of Agricultural & Food Chemistry
    • Place of Presentation
      Marriott Downtown Salt Lake City UT
    • Year and Date
      2009-03-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp) on proliferation of skin fibroblasts : A possible mechanism for improvement of skin condition by collagen peptide ingestion2009

    • Author(s)
      Yasutaka Shigemura, Kenji Sato
    • Organizer
      ACS (American Chemical Society) 2009 National Meeting & Exposition Division of Agricultural & Food Chemistry
    • Place of Presentation
      Marriott Downtown Salt Lake City UT
    • Year and Date
      2009-03-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト血液中に存在する食事由来Pro-Hypの線維芽細胞増殖促進活性2009

    • Author(s)
      重村泰毅、朴恩榮、中村考志、佐藤健司
    • Organizer
      第4回3大学連携研究発表会
    • Place of Presentation
      京都工芸繊維大学
    • Year and Date
      2009-03-17
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Growth enhancement of skin fibroblast by food derived collagen peptide in human blood2008

    • Author(s)
      Yasutaka Shigemura、Koji Iwai、Fumiki Morimatsu、Toshio Mori、Toshio Taira、Eun Young Park、Yasusi Nakamura、Kenji Sato
    • Organizer
      ISNFF (The International Society for Nutraceuticals and Functional Foods) 2008
    • Place of Presentation
      Green Laurel Hotel Taichung、Taiwan
    • Year and Date
      2008-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Growth enhancement of skin fibroblast by food derived collagen peptide in human blood2008

    • Author(s)
      Yasutaka Shigemura, Koji Iwai, Fumiki Morimatsu, Toshio Mori, Toshio Taira, Eun Young Park, Yasusi Nakamura, Kenji Sato
    • Organizer
      ISNFF (The International Society for Nutraceuticals and Functional Foods) 2008
    • Place of Presentation
      Green Laurel Hotel Taichung, Taiwan
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事由来コラーゲンペプチドが皮膚線維芽細胞増殖におよぼす影響2008

    • Author(s)
      重村泰毅
    • Organizer
      第6回高付加価値食品開発のためのフォーラム
    • Place of Presentation
      富士教育研修所
    • Year and Date
      2008-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事由来コラーゲンペプチドが皮膚線維芽細胞増殖におよぼす影響2008

    • Author(s)
      重村泰毅
    • Organizer
      日本食品機会研究会高付加価値食品開発のためのフォーラム
    • Place of Presentation
      富士教育研修所
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事由来主要コラーゲンペプチド(Pro-Hyp、Hyp-Gly)がマウス皮膚線維芽細胞増殖におよぼす影響2008

    • Author(s)
      重村泰毅、佐藤健司
    • Organizer
      2008年農芸化学会関西支部会
    • Place of Presentation
      京都学園大学
    • Year and Date
      2008-09-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事由来主要コラーゲンペプチド(Pro-Hyp, Hyp-Gly)がマウス皮膚線維芽細胞増殖におよぼす影響2008

    • Author(s)
      重村泰毅, 佐藤健司
    • Organizer
      2008年農芸化学会関西支部会
    • Place of Presentation
      京都学園大学
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp)、A Food-Derived Peptide in Human Blood、on Growth of Fibroblast2008

    • Author(s)
      Yasutaka Shigemura、Koji Iwai、Fumiki Morimatsu、Taka-aki Iwamoto、Toshio Mori、Chikako Oda、Toshio Taira、Eun Young Park、Yasusi Nakamura、Kenji Sato
    • Organizer
      IFT (Institute of Food Technologists)2008
    • Place of Presentation
      New Orleans Morial Convention Center New Orleans、Louisiana、USA
    • Year and Date
      2008-07-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp), A Food-Derived Peptide in Human Blood, on Growth of Fibroblast2008

    • Author(s)
      Yasutaka Shigemura, Koji Iwai, Fumiki Morimatsu, Taka-aki Iwamoto, Toshio Mori, Chikako Oda, Toshio Taira, Eun Young Park, Yasusi Nakamura, Kenii Sato
    • Organizer
      IFT (Institute of Food Technologists)2008
    • Place of Presentation
      New Orleans Morial Convention Center New Orleans, Louisiana, USA
    • Year and Date
      2008-07-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事由来コラーゲンペプチドPro-Hypのマウス皮膚線維芽細胞増殖への影響2008

    • Author(s)
      重村泰毅、岩井浩二、森松文毅、岩本顕 聰、森俊雄、尾田千佳子、平敏夫、朴恩榮、中村考志、佐藤健司
    • Organizer
      第62回栄養食糧学会
    • Place of Presentation
      女子栄養大学
    • Year and Date
      2008-05-03
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 創傷治療用医薬組成物2009

    • Inventor(s)
      佐藤健司、重村泰毅、島谷明子、若本裕晶
    • Industrial Property Rights Holder
      チッソ株式会社
    • Filing Date
      2009-02-28
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 創傷治療用医薬組成物2009

    • Inventor(s)
      佐藤健司、重村泰毅、中安清一朗、陶山真司、中場操子
    • Industrial Property Rights Holder
      林兼産業株式会社
    • Filing Date
      2009-03-03
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 創傷治療用医薬組成物2009

    • Inventor(s)
      佐藤健司, 重村泰毅, 島谷明子, 若本裕晶
    • Industrial Property Rights Holder
      チッソ株式会社
    • Filing Date
      2009-02-28
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 皮膚改善剤、血管機能改善剤、並びにこれらを含む医薬組成物、食品、飼料及び化粧品2009

    • Inventor(s)
      佐藤健司, 重村泰毅, 中安清三朗, 陶山真司, 中場操子
    • Industrial Property Rights Holder
      林兼産業株式会社
    • Filing Date
      2009-03-03
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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