| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The skin of a patient with Atopic dermatitis (AD) is abnormally and easily affected by irritants, food, and environmental allergens. Results from observational birth cohort studies, case-control studies, and one cluster randomized intervention trial have generally failed to demonstrate a protective effect of breastfeeding on outcomes of atopic dermatitis, allergic sensitization, wheezing, or asthma. Although these studies reported that AD correlates with breast-feeding, it is unclear whether mothers' milk itself contributes to AD development. The magnitude of Th2 adjuvant activity is associated with increased levels of cAMP in PMA-derived THP-1 cells. The short incubation period (10 min) for this assay allows for the testing of non-sterile materials such as live bacteria, or non-sterile milk, as reported in the current study.
Our study showed that some mothers, whose children developed AD within 6 months after birth, carry high Th2 adjuvant activity in their milk obtained 4 days right after birth. Such activity was not observed in mothers' milk fed to healthy infants. The current results suggest a direct effect of mothers' milk with the development of AD.
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