Evaluation of environmental factors in atopic dermatitis patients by quantitative assay for Th2 adjuvant activity
| Project/Area Number |
20710026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | Saitama Medical University |
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Principal Investigator |
HIGASHI Takehiro Saitama Medical University, 医学部, 助教 (00468381)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 環境影響評価 / 樹状細胞 / アジュバント / アトピー性皮膚炎 / 母乳 |
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| Research Abstract |
The skin of a patient with Atopic dermatitis (AD) is abnormally and easily affected by irritants, food, and environmental allergens. Results from observational birth cohort studies, case-control studies, and one cluster randomized intervention trial have generally failed to demonstrate a protective effect of breastfeeding on outcomes of atopic dermatitis, allergic sensitization, wheezing, or asthma. Although these studies reported that AD correlates with breast-feeding, it is unclear whether mothers' milk itself contributes to AD development. The magnitude of Th2 adjuvant activity is associated with increased levels of cAMP in PMA-derived THP-1 cells. The short incubation period (10 min) for this assay allows for the testing of non-sterile materials such as live bacteria, or non-sterile milk, as reported in the current study.
Our study showed that some mothers, whose children developed AD within 6 months after birth, carry high Th2 adjuvant activity in their milk obtained 4 days right after birth. Such activity was not observed in mothers' milk fed to healthy infants. The current results suggest a direct effect of mothers' milk with the development of AD.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice. Biochem2009
Author(s)
Hashimoto K, Inoue T, Higashi T, Takei S, Awata T, Katayama S, Takagi R, Okada H, Matsushita S.
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Journal Title
Biophys. Res. Commun. 383
Pages: 460-463
Related Report
Peer Reviewed
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