Role of Rev1, repair enzyme in translesion DNA synthesis, in tumorigenesis

• Project/Area Number: 20710043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Hiroshima University
• Principal Investigator: TOYOSHIMA Megumi Hiroshima University, 原爆放射線医科学研究所, 助教 (80423052)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 生物影響 / 修復 / 放射線 / マウス / 発がん / 損傷乗り越え修復 / 細胞、組織 / 化学物質 / 放射線、X線、粒子線

Research Abstract

Over-expression of Rev1 may be accelerate development of chemical induced tumors. Furthermore, over-expression of Rev1 induced the point mutation at the specific locus which was not detected in the wild-type mice.

Research Products

• [Journal Article] Paternal monoenergetic neutron exposure results in abnormal sperm, and embryonal lethality and transgenerational tumorigenesis in mouse F1 offspring (2010)
  • Author(s): Watanabe H, Toyoshima M, Ishikawa M, Kamiya K
  • Journal Title: Oncology Reports (in press)
  • Peer Reviewed
• [Journal Article] Paternal monoenergetic neutron exposure results in abnormal sperm, and embryonal lethality and transgenerational tumorigenesis in mouse F1 offspring (2010)
  • Author(s): Watanabe H, Toyoshima M, et. al.
  • Journal Title: Oncology Reports (In press)
  • Peer Reviewed
• [Journal Article] Levels of N-acylethanolamines in O, O, S- rimethylphosphorothioate (OOS-TMP)- treated C57BL/6J mice and potential anti-obesity, anti-diabetic effects of OOS-TMP in hyperphagia and hyperglycemia mouse models (2009)
  • Author(s): Huang L, Toyoshima M, Asakawa A, Inoue K, Harada K, Kinoshita T, Chen S, Koizumi A
  • Journal Title: Pharmacol Biochem Behav 92(1) Pages: 1-5
  • Peer Reviewed
• [Journal Article] Cleft palate caused by perfluorooctane sulfonate is caused mainly by extrinsic factors (2009)
  • Author(s): Era S, Harada KH, Toyoshima M, Inoue K, Minata M, Saito N, Takigawa T, Shiota K, Koizumi A
  • Journal Title: Toxicology 4;256(1-2) Pages: 42-7
  • Peer Reviewed
• [Journal Article] Analysis of p53 dependent damage response in sperm-irradiated mouse embryos (2009)
  • Author(s): Toyoshima M
  • Journal Title: Journal of radiation research 50(1) Pages: 11-17
  • NAID: 110007042078
  • Peer Reviewed
• [Journal Article] Analysis of p53 dependent damage response in sperm-irradiated mouse embryos (2009)
  • Author(s): Toyoshima M
  • Journal Title: Journal of radiation research 50・1 Pages: 11-17
  • NAID: 110007042078
  • Peer Reviewed
• [Journal Article] Cleft palate caused by perfluorooctane sulfonate is caused mainly by extrinsic factors (2009)
  • Author(s): Era S
  • Journal Title: Toxicology 256・1・2 Pages: 42-47
  • Peer Reviewed
• [Journal Article] S期チェックポイント機構における最近の知見 (2008)
  • Author(s): 豊島めぐみ、神谷研二、丹羽太貫
  • Journal Title: 放射線生物研究 43(3) Pages: 223-35
  • NAID: 40016267798
  • Peer Reviewed
• [Journal Article] 損傷乗り越えDNA合成酵素Rev1の突然変異誘発への寄与 (2008)
  • Author(s): 豊島めぐみ, 習陽, 久保圭, 濱崎幹也, 楠洋一郎, 本田浩章, 増田雄司, 渡邊敦光, 神谷研二
  • Journal Title: 長崎医学会雑誌 Pages: 367-369
  • Peer Reviewed
• [Journal Article] Radiation induction of delayed recombination in Schizosaccharomyces pombe (2008)
  • Author(s): Takeda J, Uematsu N, Shiraishi S, Toyoshima M, Matsumoto T, Niwa O
  • Journal Title: DNA repair 7(8) Pages: 1250-61
  • Peer Reviewed
• [Journal Article] The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator- activated receptor-alpha (2008)
  • Author(s): Asakawa A, Toyoshima M, Harada KH, Fujimiya M, Inoue K, Koizumi A
  • Journal Title: Int. J. Mol. Med 21(4) Pages: 439-45
  • Peer Reviewed
• [Journal Article] The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha (2008)
  • Author(s): Asakawa A
  • Journal Title: Int. J. Mol. Med. 21・4 Pages: 439-445
  • Peer Reviewed
• [Journal Article] Radiation induction of delayed recombination in Schizosaccharomyces pombe (2008)
  • Author(s): Takeda J
  • Journal Title: DNA repair 7・8 Pages: 1250-1261
  • Peer Reviewed
• [Journal Article] 損傷乗り越えポリメラーゼRev1の放射線発がんに与える影響
  • Author(s): 豊島めぐみ, 習陽, 三家本隆宏, 渡邊敦光, 増田雄司, 本田浩章, 濱崎幹也, 楠洋一郎, 神谷研二
  • Journal Title: 広島医学 (in press)
  • Peer Reviewed
• [Journal Article] 損傷乗り越えポリメラーゼRev1の過剰発現が放射線による突然変異誘発に与える影響
  • Author(s): 三家本隆宏, 豊島めぐみ, 習陽, 本田浩章, 濱崎幹也, 楠洋一郎, 神谷研二
  • Journal Title: 広島医学 (in press)
  • Peer Reviewed
• [Presentation] 放射線発がん、化学発がんにおける損傷乗り越えDNA合成酵素Rev1の役割 (2009)
  • Author(s): 豊島めぐみ
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] 損傷乗り越えDNA合成酵素Rev1過剰発現への寄与 (2009)
  • Author(s): 豊島めぐみ
  • Organizer: 第20回DNA複製・組換え・修復ワークショップ
  • Place of Presentation: 彦根
  • Year and Date: 2009-11-11
• [Presentation] Rev1の過剰発現はMNUによる小腸腫瘍誘発を促進する (2009)
  • Author(s): 豊島めぐみ
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 損傷乗り越えDNA合成酵素Rev1過剰発現が化学発がん、放射線発がんに及ぼす影響 (2009)
  • Author(s): 豊島めぐみ
  • Organizer: 第34回中国地区放射線影響研究会
  • Place of Presentation: 広島
  • Year and Date: 2009-07-29
• [Presentation] 損傷乗り越えポリメラーゼRev1の放射線発がんに与える影響 (2009)
  • Author(s): 豊島めぐみ
  • Organizer: 第50回原子爆弾後障害研究会
  • Place of Presentation: 広島
  • Year and Date: 2009-06-07
• [Presentation] Function of Rev1 on Carcinogenesis induced by ionizing radiation and chemical agents (2009)
  • Author(s): Toyoshima M
  • Organizer: 2nd Asian Congress of Radiation Research (ACRR 2009)
  • Place of Presentation: Seoul
  • Year and Date: 2009-05-17
• [Presentation] Function of Rev1 on Carcinogenesis induced by ionizing radiation and chemical agents (2009)
  • Author(s): Toyoshima M
  • Organizer: 2nd Asian Congress of Radiation Research (ACRR 2009)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-17
• [Presentation] 損傷乗り越えDNA合成酵素Rev1過剰発現マウスにおける発がん機構解明 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-12-12
• [Presentation] 損傷乗り越えDNA合成酵素月Rev1過剰発現マウスにおける発がん機構解明 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-12-12
• [Presentation] The Role of Rev1 in Tumorigenesis International Workshop on (2008)
  • Author(s): 豊島めぐみ
  • Organizer: Radiation Health Effects Research -47th ISTC Japan Workshop-
  • Place of Presentation: 長崎
  • Year and Date: 2008-12-01
• [Presentation] The Role of Revl in Tumorigenesis (2008)
  • Author(s): 豊島めぐみ
  • Organizer: International Workshop on Radiation Health Effects Research-47th ISTC Japan Workshop-
  • Place of Presentation: 長崎
  • Year and Date: 2008-12-01
• [Presentation] 損傷乗り越えDNA合成酵素Rev1の放射線応答 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 放射線発がんにおける寄与日本放射線影響学会第51回大会
  • Place of Presentation: 北九州
  • Year and Date: 2008-11-20
• [Presentation] 損傷乗り越えDNA合成酵素Rev1の放射線応答、放射線発がんにおける寄与 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州
  • Year and Date: 2008-11-20
• [Presentation] 発がんにおける損傷乗り越えDNA合成酵素Rev1の役割 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 放射線がん、化学発がんにおける損傷乗り越えDNA合成酵素Rev1の寄与 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 第33回中国地区放射線影響研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-07-30
• [Presentation] 損傷乗り越えDNA合成酵素Rev1の発がんにおける役割 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 変異機構研究会・第21回夏の学校
  • Place of Presentation: 小牧
  • Year and Date: 2008-06-14
• [Presentation] 損傷乗り越えDNA合成酵素Rev1の突然変異誘発への寄与 (2008)
  • Author(s): 豊島めぐみ
  • Organizer: 第49回原子爆弾後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2008-06-08