Role of Rev1, repair enzyme in translesion DNA synthesis, in tumorigenesis
Project/Area Number |
20710043
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Hiroshima University |
Principal Investigator |
TOYOSHIMA Megumi Hiroshima University, 原爆放射線医科学研究所, 助教 (80423052)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 生物影響 / 修復 / 放射線 / マウス / 発がん / 損傷乗り越え修復 / 細胞、組織 / 化学物質 / 放射線、X線、粒子線 |
Research Abstract |
Over-expression of Rev1 may be accelerate development of chemical induced tumors. Furthermore, over-expression of Rev1 induced the point mutation at the specific locus which was not detected in the wild-type mice.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Levels of N-acylethanolamines in O, O, S- rimethylphosphorothioate (OOS-TMP)- treated C57BL/6J mice and potential anti-obesity, anti-diabetic effects of OOS-TMP in hyperphagia and hyperglycemia mouse models2009
Author(s)
Huang L, Toyoshima M, Asakawa A, Inoue K, Harada K, Kinoshita T, Chen S, Koizumi A
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Journal Title
Pharmacol Biochem Behav 92(1)
Pages: 1-5
Related Report
Peer Reviewed
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