| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
To investigate the molecular mechanisms of p53 ubiquitination, a novel in vitro assay system has been established. Using this assay system, we have found out more about how P53 is ubiquitinated by MDM2 and MDMX. Furthermore, alteration of the amount of cellular MDMX significantly affects on the response of p53 to genotoxic stress. Taken together, these results indicate that MDMX is indispensable for the regulation of the P53 response to genotoxic stress.
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