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Analysis of a novel mechanism for the p53 response to radiation by the MDM2-MDMX E3 ubiquitin ligase complex

Research Project

Project/Area Number 20710044
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

KAWAI Hidehiko  Hiroshima University, 原爆放射線医科学研究所, 助教 (30379846)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords放射線 / がん / P53 / MDM2 / ユビキチン化修飾 / p53 / MDM2-MDMX複合体 / 放射線応答
Research Abstract

To investigate the molecular mechanisms of p53 ubiquitination, a novel in vitro assay system has been established. Using this assay system, we have found out more about how P53 is ubiquitinated by MDM2 and MDMX. Furthermore, alteration of the amount of cellular MDMX significantly affects on the response of p53 to genotoxic stress. Taken together, these results indicate that MDMX is indispensable for the regulation of the P53 response to genotoxic stress.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Presentation (5 results)

  • [Presentation] MDM2ファミリーによるP53の安定性と放射線応答の制御機構2009

    • Author(s)
      河合秀彦
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Analysis of the molecular mechanism of p53 ubiquitination by the MDM2-MDMX E3 ubiquitin ligase complex2009

    • Author(s)
      河合秀彦
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      ソウル(大韓民国)
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] MDM2-MDMX複合体とE3ユビキチンリガーゼ活性2008

    • Author(s)
      河合秀彦
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] p53制御機構におけるMDM2/MDMXヘテロ複合体の機能解析2008

    • Author(s)
      河合秀彦
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Year and Date
      2008-11-19
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] The functional analysis of the MDM2-MDMX complex as an E3 ubiquitin ligase for p532008

    • Author(s)
      河合秀彦
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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