| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Ionizing radiation induces genomic instability in the progeny of irradiated cells. The evidence has been accumulated to suggest that the induction of DNA double-strand breaks (DSBs) and subsequent repair processes play a key role in inducing genomic instability. In the present study, we hypothesize that some DNA lesions remained after repair of DSBs might be related to the induction of genomic instability. To study a role of clustered damage in the induction of chromosomal instability, we transferred an UVA-irradiated human chromosome 21 into unirradiated mouse m5S cells derived from mouse fibroblasts, using a microcell-mediated chromosome transfer.
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