| Project/Area Number |
20710046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
NISHIKINO Masaharu Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 (70370450)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | レーザープラズマX線 / 軟X線レーザー / 放射線生物影響 / マイクロビーム / DNA二本鎖切断 / バイスタンダー効果 / 放射線影響 / 2本鎖切断 |
|---|
| Research Abstract |
A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV and 90 eV in energy x-ray pulses generated with a short pulse laser were used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source. To elucidate the bystander effects, we have observed the propagation of stress responses.
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