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Bystander effect induced by Laser plasma x-ray beam and soft x-ray laser beam

Research Project

Project/Area Number 20710046
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

NISHIKINO Masaharu  Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 (70370450)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsレーザープラズマX線 / 軟X線レーザー / 放射線生物影響 / マイクロビーム / DNA二本鎖切断 / バイスタンダー効果 / 放射線影響 / 2本鎖切断
Research Abstract

A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV and 90 eV in energy x-ray pulses generated with a short pulse laser were used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source. To elucidate the bystander effects, we have observed the propagation of stress responses.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Application of Laser Produced Plasma Kα X-ray Probe in Radiation Biology2010

    • Author(s)
      Masaharu Nishikino, et al., (他9名)
    • Journal Title

      Review of Scientific Instruments Vol.81

      Pages: 20266217-20266217

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of Laser Produced Plasma Kα X-ray Probe in Radiation Biology2010

    • Author(s)
      Masaharu Nishikino et al.
    • Journal Title

      Review of Scientific Instruments 81

      Pages: 20266217-20266217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Laser Plasma2009

    • Author(s)
      Masaharu Nishikino, et al., (他9名)
    • Journal Title

      X-ray Beam for Radiobiological Applications

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Focused Laser Plasma X-ray Beam for Radiobiological Applications2009

    • Author(s)
      Masaharu Nishikino, et al., (他9名)
    • Journal Title

      Journal of Radiation Research vol.50A

    • NAID

      10025913784

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Laser Plasma X-ray Beam for Radiobiological Applications2009

    • Author(s)
      Masaharu Nishikino et al.
    • Journal Title

      Proceedings of OLEO Pacific Rim 2009 (CD-ROM)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Focused Laser Plasma X-ray Beam for Radiobiological Applications2009

    • Author(s)
      Masaharu Nishikino, et al.
    • Journal Title

      Journal of Radiation Research vol.50A

    • NAID

      10025913784

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Soft X-ray Fourier Transform Holography with Fresnel Zone Plate2009

    • Author(s)
      Masaharu Nishikino, et al.
    • Journal Title

      Proceedings of 10th International Conference on X-ray Lasers (未定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Soft X-ray Fourier Transform Holography with Fresnel Zone Plate2008

    • Author(s)
      Masaharu Nishikino, et al., (他3名)
    • Journal Title

      X-Ray Lasers

      Pages: 427-432

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] レーザー駆動単色x線と放射線生物学への応用2010

    • Author(s)
      錦野将元
    • Organizer
      第57回応用物理学関係連合講演会
    • Place of Presentation
      東海大学
    • Year and Date
      2010-03-18
    • Related Report
      2009 Final Research Report
  • [Presentation] レーザー駆動単色X線と放射線生物学への応用2010

    • Author(s)
      錦野将元, 他
    • Organizer
      第57回 応用物理学関係連合講演会
    • Place of Presentation
      神奈川、日本(東海大学)
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超短パルスレーザープラズマx線ビームの放射線生物影響研究への応用2010

    • Author(s)
      錦野将元
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2010-02-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 超短パルスレーザープラズマX線ビームの放射線生物影響研究への応用2010

    • Author(s)
      錦野将元, 他
    • Organizer
      レーザー学会 学術講演会第30回年次大会
    • Place of Presentation
      大阪、日本(千里ライフサイエンスセンター)
    • Year and Date
      2010-02-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線生物応用研究に向けた超短パルスレーザープラズマx線ビームの開発2009

    • Author(s)
      錦野将元
    • Organizer
      高速度イメージングとフォトニクスに関する総合シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 放射線生物応用研究に向けた超短パルスレーザープラズマX線ビームの開発2009

    • Author(s)
      錦野将元, 他
    • Organizer
      高速度イメージングとフォトニクスに関する総合シンポジウム
    • Place of Presentation
      大阪、日本(大阪大学)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Laser Plasma X-ray Beam for Radiobiological Applications2009

    • Author(s)
      Masaharu Nishikino
    • Organizer
      CLEO Pacific Rim 2009
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2009-09-01
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] レーザープラズマx線マイクロビーム照射装置の開発と放射線生物学への応用2008

    • Author(s)
      錦野将元
    • Place of Presentation
      九州大学
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] レーザープラズマX線マイクロビーム照射装置の開発と放射線生物学への応用2008

    • Author(s)
      錦野将元, 他
    • Organizer
      レーザー励起輻射の物理とその応用研究会
    • Place of Presentation
      福岡、日本(九州大学)
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Focused Laser Plasma X-ray Beam for Radiobiological Applications2008

    • Author(s)
      Masaharu Nishikino
    • Place of Presentation
      放射線医学総合研究所
    • Year and Date
      2008-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of Focused Laser Plasma X-ray Beam for Radiobiological Applications2008

    • Author(s)
      Masaharu Nishikino, et al.
    • Organizer
      8th International Workshop on Microbeam Probes of Cellular Radiation Response
    • Place of Presentation
      千葉、日本(放射線医学総合研究所)
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Soft X-ray Fourier Transform Holography with Fresnel Zone Plate2008

    • Author(s)
      Masaharu Nishikino, et al.
    • Organizer
      11th International Conference on X-ray Lasers
    • Place of Presentation
      Belfast, Northern Ireland (Queen's University)
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Soft X-ray Fourier Transform Holography with Fresnel Zone Plate2008

    • Author(s)
      Masaharu Nishikino
    • Organizer
      11th Internatiolnal Conferenece on X-ray Lasers
    • Place of Presentation
      Belfast, Northern Ireland
    • Year and Date
      2008-08-19
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 放射線照射試料用シャーレ及び放射線照射方法2009

    • Inventor(s)
      錦野将元
    • Industrial Property Rights Holder
      日本原子力研究開発機構
    • Filing Date
      2009-09-25
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 放射線照射試料用シャーレ及び放射線照射方法2009

    • Inventor(s)
      錦野将元, 他
    • Industrial Property Rights Holder
      日本原子力研究開発機構
    • Industrial Property Number
      2009-220831
    • Filing Date
      2009-09-25
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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