| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Biological effects of ionizing radiation per dose are larger in high-LET heavy ions than in low-LET radiations. As a reason of this phenomenon, radiation biologists believe that heavy ions induce localized DNA damage which is difficult to repair in irradiated cells. However, the conventional experimental techniques such as pulsed-field gel electrophoresis could not quantify radiation-induced DNA fragmentation that cuts genomic DNA shorter than 10 kbp. In the present study, I have found that most of DNA fragments shorter than 10 kbp were lost during genomic DNA preparation.
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