| Project/Area Number |
20710052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Ehime University |
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Principal Investigator |
NAKAYAMA Kei Ehime University, 沿岸環境科学研究センター, 講師 (80380286)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | マイクロアレイ / 環境 / 農林水産物 / 有害化学物質 / トキシコゲノミクス |
|---|
| Research Abstract |
In the present study, we investigated the early life stage toxicity of hydroxylated polychlorinated biphenyls (OH-PCBs), metabolites of PCBs, using Japanese flounder embryos. The exposure test revealed that more than 1 ppb of an isomer of OH-PCBs, 4-hydroxy-2',3,5,5'-tetrachlorobiphenyl, caused malformation of peripheral nervous system in head part of flounders. The present study suggests that OH-PCBs could disrupt thyroid hormone functions in vivo as well as in vitro.
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