The binding mechanism of endocrine disruptors to protein disulfide isomerase and its physiological effects.
| Project/Area Number |
20710054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
OKADA Kazushi Kwansei Gakuin University, 理工学研究科, 博士研究員 (40423892)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 内分泌かく乱物質 / 環境化学物質 / 内分泌かく乱化学物質 / ビスフェノールA / タンパク質フォールディング / PDI / 分子シャペロン / 甲状腺ホルモン / 脳神経変性疾患 / 環境 / 生体分子 / フオールデイング / 内分泌撹乱化学物質 / 酵素 |
|---|
| Research Abstract |
We investigated the S-nitrosylation of PDI by bisphenol A in GH3 cells. S-nitrosylated PDI (SNO-PDI) was increased by 24h-treatment of bisphenol A in the presence of T_3, although not increased by T_3 only.
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Report
(3 results)
Research Products
(26 results)
