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The binding mechanism of endocrine disruptors to protein disulfide isomerase and its physiological effects.

Research Project

Project/Area Number 20710054
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKwansei Gakuin University

Principal Investigator

OKADA Kazushi  Kwansei Gakuin University, 理工学研究科, 博士研究員 (40423892)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords内分泌かく乱物質 / 環境化学物質 / 内分泌かく乱化学物質 / ビスフェノールA / タンパク質フォールディング / PDI / 分子シャペロン / 甲状腺ホルモン / 脳神経変性疾患 / 環境 / 生体分子 / フオールデイング / 内分泌撹乱化学物質 / 酵素
Research Abstract

We investigated the S-nitrosylation of PDI by bisphenol A in GH3 cells. S-nitrosylated PDI (SNO-PDI) was increased by 24h-treatment of bisphenol A in the presence of T_3, although not increased by T_3 only.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (16 results)

  • [Journal Article] Biological functions of protein disulfide isomerase as a target of phenolic endocrine-disrupting chemicals.2010

    • Author(s)
      Okada K, Hashimoto S, Imaoka S
    • Journal Title

      J Health Sci. 56(1)

      Pages: 1-13

    • NAID

      130000157697

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LKM-1 sera from autoimmune hepatitis patients recognize ERp57 and carboxylesterase 1 as well as CYP2D6.2010

    • Author(s)
      Komurasaki R, Imaoka S, Tada N, Okada K, Nishiguchi S, Funae Y
    • Journal Title

      Drug Metab Pharmacokinet 25(1)

      Pages: 84-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biological functions of protein disulfide isomerase as a target of phenolic endocrine-disrupting chemicals2010

    • Author(s)
      Okada K
    • Journal Title

      Journal of Health Science 56(1)

      Pages: 1-13

    • NAID

      130000157697

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LKM-1 sera from autoimmune hepatitis patients recognize ERp57 andcarboxylesterase 1 as well as CYP2D62010

    • Author(s)
      Komurasaki R
    • Journal Title

      Drug Metabolism and Pharmacokinetics 25(1)

      Pages: 84-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis.2009

    • Author(s)
      Baba K, Okada K, Kinoshita T, Imaoka S
    • Journal Title

      Toxicol Sci. 108(2)

      Pages: 344-355

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylated polychlorinatedbiphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity.2009

    • Author(s)
      Okada K, Hashimoto S, Funae Y, Imaoka S
    • Journal Title

      Chem Res Toxicol 22(5)

      Pages: 899-904

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bisphenol A disrupts Notch signa ling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis2009

    • Author(s)
      Baba K
    • Journal Title

      Toxicological Sciences 108(2)

      Pages: 344-355

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity2009

    • Author(s)
      Okada K
    • Journal Title

      Chemical Research in Toxicology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between bisphenol derivatives and protein disulphide isomerase (PDI) and inhibition of PDI functions: requirement of chemical structure for binding to PDI.2008

    • Author(s)
      Hashimoto S, Okada K, Imaoka S
    • Journal Title

      J Biochem 144(3)

      Pages: 335-342

    • NAID

      10024912198

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between bisphenol derivatives and protein disulfide isomerase (PDI) and inhibition of PDI functions : requirement of chemical structure for binding to PDI2008

    • Author(s)
      Hashimoto S
    • Journal Title

      Journal of Biochemistry 144(3)

      Pages: 335-342

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ブロム化難燃剤の甲状腺ホルモン撹乱活性発現における構造活性相関2009

    • Author(s)
      浦丸直人、岩瀬恵理、佐能正剛、杉原数美、岡田和嗣、今岡進、太田茂、北村繁幸
    • Organizer
      環境ホルモン学会第12回研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] TR, PDIへの親和性に対する臭素化難燃剤の構造活性相関2009

    • Author(s)
      岩瀬恵理、佐能正剛、岡田和嗣、今岡進、加藤善久、小島弘幸、浦丸直人、杉原数美、北村繁幸、黒木広明、太田茂
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] GH3細胞における Protein disulfide isomerase による甲状腺ホルモン応答制御機構について2009

    • Author(s)
      橋本翔子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質ジスルフィドイソメラーゼ(PDI)のS-ニトロシル化による成長ホルモン産生機構および環境化学物質の影響2009

    • Author(s)
      岡田和嗣、橋本翔子、今岡進
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ビスフェノールA結合タンパク質PDIとその相同タンパク質ERp57, ERp72の機能解析2009

    • Author(s)
      佐々木淑絵、橋本翔子、岡田和嗣、今岡進
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] causes aberrant S-nitrosylation of protein disulfide isomerase in GH3 cells.2009

    • Author(s)
      Okada K, Hashimoto S, Imaoka S. Bisphenol A
    • Organizer
      The 4th international congress on stress responses in biology and medicine. The 4th annual meeting of the biomedical society for stress response
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Bisphenol A causes aberrant S-nitrosylation of protein disulfide isomerase in GH3 cells2009

    • Author(s)
      岡田和嗣
    • Organizer
      The 4th annual meeting of the biomedical society for stress response in biology and medicine
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibition mechanism of PDI functions by bisphenols.2009

    • Author(s)
      Hashimoto S, Okada K, Imaoka S
    • Organizer
      The 4th international congress on stress responses in biology and medicine. The 4th annual meeting of the biomedical society for stress response
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Inhibition mechanism of PDI functions by bisphenols2009

    • Author(s)
      橋本翔子
    • Organizer
      The 4th annual meeting of the biomedical society for stress response in biology and medicine
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] PDI, ERp57, and ERp72, multifunctional protein disulfide isomerase, reveal different interaction with bisphenol A.2009

    • Author(s)
      Sasaki Y, Hashimoto S, Okada K, Imaoka S
    • Organizer
      The 4th international congress on stress responses in biology and medicine. The 4th annual meeting of the biomedical society for stress response
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-06
    • Related Report
      2009 Final Research Report
  • [Presentation] PDI, ERp57, and ERp72, multifunctional protein disulfide isomerase, reveal different interaction with bisphenol A2009

    • Author(s)
      佐々木淑恵
    • Organizer
      The 4th annual meeting of the biomedical society for stress response in biology and medicine
    • Place of Presentation
      北海道
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein disulfide isomerase(PDI)のビスフェノールA及びT_3結合ドメインの同定と生理機能解析2008

    • Author(s)
      橋本翔子
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] PDIとカルレティキュリンの相互作用に及ぼすビスフェノールAの影響2008

    • Author(s)
      岡田和嗣、幸田秀紀、今岡進
    • Organizer
      日本トキシコロジー学会第35回学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] . プロテインジスルフィドイソメラーゼ(PDI)へのビスフェノールA類縁体結合能と酵素活性について2008

    • Author(s)
      橋本翔子, 岡田和嗣, 今岡進
    • Organizer
      日本トキシコロジー学会第35回学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2009 Final Research Report
  • [Presentation] フェノール性環境化学物質による発生異常のメカニズム解析2008

    • Author(s)
      馬場一信, 岡田和嗣, 今岡進
    • Organizer
      日本トキシコロジー学会第35回学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] プロテインジスルフィドイソメラーゼ(PDI)へのビスフェノールA類縁体結合能と酵素活性について2008

    • Author(s)
      橋本翔子
    • Organizer
      日本トキシコロジー学会第35回学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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